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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
2981

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:2981

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:2981
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0031691alpha-1A adrenergic receptor bindingArrb1IPIRGD:736081RatRGD:5510010|PMID:18523139
Molecular FunctionGO:0031692alpha-1B adrenergic receptor bindingArrb1IDARatRGD:5510010|PMID:18523139
Molecular FunctionGO:0031701angiotensin receptor bindingARRB1IPIUniProtKB:P30556HumanPMID:15611106
Molecular FunctionGO:0035612AP-2 adaptor complex bindingArrb1IDARatRGD:1601545|PMID:15728179
Molecular FunctionGO:0035615clathrin adaptor activityArrb1IDARatRGD:1601545|PMID:15728179
Molecular FunctionGO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic processArrb1IMPMouseMGI:MGI:4453294|PMID:19915011
Molecular FunctionGO:0030331estrogen receptor bindingArrb1IPIRGD:2581RatRGD:5509970|PMID:19339617
Molecular FunctionGO:0031762follicle-stimulating hormone receptor bindingArrb1IPIRGD:2632RatRGD:4140424|PMID:16899567
Molecular FunctionGO:0005096GTPase activator activityARRB1IMPHumanPMID:15611106
Molecular FunctionGO:0005159insulin-like growth factor receptor bindingARRB1IPIUniProtKB:P08069HumanPMID:15878855
Molecular FunctionGO:0044325ion channel bindingArrb1IPIRGD:69337RatRGD:5509917|PMID:20650893
Molecular FunctionGO:0031434mitogen-activated protein kinase kinase bindingArrb1IDAMouseMGI:MGI:4453294|PMID:19915011
Molecular FunctionGO:0051219phosphoprotein bindingArrb1IPIUniProtKB:O14640RatRGD:8554243|PMID:11742073
Molecular FunctionGO:0051219phosphoprotein bindingArrb1IPIUniProtKB:O14641RatRGD:8554243|PMID:11742073
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:O43298HumanPMID:16189514
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q14749HumanPMID:16189514
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q9Y4K3HumanPMID:16378096
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P51810HumanPMID:16524428
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:O75688HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:O95218HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P06396HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P06702HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P11142HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P14618HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P19338HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P27348HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P35813HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P62158HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q13428HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q13523HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q14978HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q15208HumanPMID:17620599
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q8TEY7HumanPMID:19363159
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P53779HumanPMID:19782076
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q99683HumanPMID:19782076
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P25490HumanPMID:19879840
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P53779HumanPMID:19879840
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q16665HumanPMID:21685944
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P45984HumanPMID:21988832
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q14749HumanPMID:21988832
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P25106HumanPMID:22457824
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q9NPB9HumanPMID:23341447
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P50148HumanPMID:23353685
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q5JWF2HumanPMID:23353685
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P20963HumanPMID:24502978
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:P45984HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingARRB1IPIUniProtKB:Q7DB77HumanPMID:25519916
Molecular FunctionGO:0005515protein bindingArrb1IPIUniProtKB:Q04736MouseMGI:MGI:2153592|PMID:11546805
Molecular FunctionGO:0005515protein bindingArrb1IPIUniProtKB:O35387|UniProtKB:O54946|UniProtKB:P23804|UniProtKB:Q60795MouseMGI:MGI:3688344|PMID:15102471
Molecular FunctionGO:0005515protein bindingArrb1IPIUniProtKB:Q61614MouseMGI:MGI:2153592|PMID:11546805
Molecular FunctionGO:0005515protein bindingArrb1IPIRGD:620218RatRGD:10059408|PMID:21223624
Molecular FunctionGO:0005515protein bindingArrb1IPIUniProtKB:P53667RatRGD:8554055|PMID:17500066
Molecular FunctionGO:0005515protein bindingArrb1IPIUniProtKB:Q96GD0RatRGD:8554055|PMID:17500066
Molecular FunctionGO:0045309protein phosphorylated amino acid bindingArrb1IMPRatRGD:5490984|PMID:17513300
Molecular FunctionGO:0008134transcription factor bindingARRB1IPIUniProtKB:P16220HumanPMID:16325578
Molecular FunctionGO:0044212transcription regulatory region DNA bindingARRB1IMPHumanPMID:16325578
Molecular FunctionGO:0031625ubiquitin protein ligase bindingARRB1IPIUniProtKB:Q00987HumanPMID:15878855
Molecular FunctionGO:0031896V2 vasopressin receptor bindingArrb1IMPRatRGD:5490984|PMID:17513300
Cellular ComponentGO:0016323basolateral plasma membraneArrb1IDARatRGD:4140424|PMID:16899567
Cellular ComponentGO:0000785chromatinARRB1IDAHumanPMID:16325578
Cellular ComponentGO:0005737cytoplasmARRB1IDAHumanPMID:10823817
Cellular ComponentGO:0005737cytoplasmARRB1IDAHumanPMID:15611106
Cellular ComponentGO:0005737cytoplasmARRB1IDAHumanPMID:16325578
Cellular ComponentGO:0005737cytoplasmArrb1IDARatRGD:4140424|PMID:16899567
Cellular ComponentGO:0031410cytoplasmic vesicleARRB1IDAHumanPMID:15611106
Cellular ComponentGO:0005829cytosolArrb1IDAMouseMGI:MGI:4453294|PMID:19915011
Cellular ComponentGO:0005829cytosolArrb1IDARatRGD:1578803|PMID:15514408
Cellular ComponentGO:0043197dendritic spineArrb1IDARatRGD:631708|PMID:1517224
Cellular ComponentGO:0005622intracellularArrb1IDAMouseMGI:MGI:1930835|PMID:11171997
Cellular ComponentGO:0016604nuclear bodyARRB1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005654nucleoplasmARRB1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusARRB1IDAHumanPMID:16325578
Cellular ComponentGO:0005634nucleusArrb1IDARatRGD:10059408|PMID:21223624
Cellular ComponentGO:0014069postsynaptic densityArrb1IDARatRGD:631708|PMID:1517224
Cellular ComponentGO:0045211postsynaptic membraneArrb1IDARatRGD:631708|PMID:1517224
Cellular ComponentGO:0031143pseudopodiumArrb1IDAMouseMGI:MGI:2673740|PMID:12821670
Biological ProcessGO:0000187activation of MAPK activityArrb1IDARatRGD:1304268|PMID:12519791
Biological ProcessGO:0000187activation of MAPK activityArrb1IDARatRGD:631797|PMID:12167719
Biological ProcessGO:0006897endocytosisArrb1IDARatRGD:1304268|PMID:12519791
Biological ProcessGO:0042699follicle-stimulating hormone signaling pathwayArrb1IDARatRGD:4140424|PMID:16899567
Biological ProcessGO:0002031G-protein coupled receptor internalizationARRB1IMPHumanPMID:10521508
Biological ProcessGO:0002031G-protein coupled receptor internalizationARRB1IMPHumanPMID:12582207
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayArrb1IDARatRGD:631708|PMID:1517224
Biological ProcessGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic processArrb1IMPMouseMGI:MGI:4453294|PMID:19915011
Biological ProcessGO:0070373negative regulation of ERK1 and ERK2 cascadeArrb1IMPRatRGD:5509898|PMID:19254952
Biological ProcessGO:0034260negative regulation of GTPase activityArrb1IDARatRGD:631708|PMID:1517224
Biological ProcessGO:0032715negative regulation of interleukin-6 productionARRB1IDAHumanPMID:16378096
Biological ProcessGO:0032717negative regulation of interleukin-8 productionARRB1IDAHumanPMID:16378096
Biological ProcessGO:0032088negative regulation of NF-kappaB transcription factor activityARRB1IDAHumanPMID:16378096
Biological ProcessGO:0001933negative regulation of protein phosphorylationArrb1IMPRatRGD:5509898|PMID:19254952
Biological ProcessGO:0031397negative regulation of protein ubiquitinationARRB1IDAHumanPMID:16378096
Biological ProcessGO:0007602phototransductionArrb1IMPMGI:MGI:2388373MouseMGI:MGI:3772638|PMID:11853756
Biological ProcessGO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic processArrb1IMPRatRGD:5510006|PMID:19171933
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeARRB1IDAHumanPMID:10644702
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeArrb1IMPMouseMGI:MGI:4453294|PMID:19915011
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeArrb1IMPRatRGD:5509998|PMID:19289825
Biological ProcessGO:0035066positive regulation of histone acetylationARRB1IMPHumanPMID:16325578
Biological ProcessGO:0090240positive regulation of histone H4 acetylationARRB1IMPHumanPMID:16325578
Biological ProcessGO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulusArrb1IMPMouseMGI:MGI:4453294|PMID:19915011
Biological ProcessGO:0033138positive regulation of peptidyl-serine phosphorylationArrb1IMPMouseMGI:MGI:4453294|PMID:19915011
Biological ProcessGO:0032092positive regulation of protein bindingArrb1IMPMouseMGI:MGI:4453294|PMID:19915011
Biological ProcessGO:0001934positive regulation of protein phosphorylationARRB1IMPHumanPMID:23633677
Biological ProcessGO:0031398positive regulation of protein ubiquitinationArrb1IMPRatRGD:5509917|PMID:20650893
Biological ProcessGO:0002092positive regulation of receptor internalizationARRB1IMPHumanPMID:22457824
Biological ProcessGO:0035025positive regulation of Rho protein signal transductionARRB1IMPHumanPMID:15611106
Biological ProcessGO:0034393positive regulation of smooth muscle cell apoptotic processArrb1IMPRatRGD:5510006|PMID:19171933
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterARRB1IMPHumanPMID:16325578
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterArrb1IDARatRGD:8554401|PMID:16325578
Biological ProcessGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic processARRB1IMPHumanPMID:15878855
Biological ProcessGO:0016567protein ubiquitinationARRB1IMPHumanPMID:15878855
Biological ProcessGO:0042981regulation of apoptotic processArrb1IMPMouseMGI:MGI:4453294|PMID:19915011
Biological ProcessGO:0008277regulation of G-protein coupled receptor protein signaling pathwayArrb1IMPMGI:MGI:2157962MouseMGI:MGI:1930835|PMID:11171997
Biological ProcessGO:0008277regulation of G-protein coupled receptor protein signaling pathwayArrb1IMPMGI:MGI:2157962MouseMGI:MGI:1101531|PMID:9400383
Biological ProcessGO:0008277regulation of G-protein coupled receptor protein signaling pathwayArrb1IDARatRGD:631708|PMID:1517224
Biological ProcessGO:0043149stress fiber assemblyARRB1IMPHumanPMID:15611106
Biological ProcessGO:0006366transcription from RNA polymerase II promoterARRB1IMPHumanPMID:16325578
Biological ProcessGO:0006366transcription from RNA polymerase II promoterArrb1IDARatRGD:8554243|PMID:11742073

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory