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Comparative GO Graph (mouse, human)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
1925

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:1925

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Aug 5 20:57:06 2014.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:1925
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005524ATP bindingP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:2667237|PMID:12677010
Molecular FunctionGO:0015267channel activityP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3797675|PMID:18519738
Molecular FunctionGO:0004931extracellular ATP-gated cation channel activityP2RX7IDAHumanPMID:9038151
Molecular FunctionGO:0004931extracellular ATP-gated cation channel activityP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:2667237|PMID:12677010
Molecular FunctionGO:0004931extracellular ATP-gated cation channel activityP2rx7IMPMouseMGI:MGI:3529714|PMID:15713258
Molecular FunctionGO:0001530lipopolysaccharide bindingP2rx7IDAMouseMGI:MGI:2148354|PMID:11489964
Molecular FunctionGO:0005515protein bindingP2rx7IPIUniProtKB:P23242MouseMGI:MGI:3053262|PMID:15331634
Molecular FunctionGO:0001614purinergic nucleotide receptor activityP2RX7IDAHumanPMID:9038151
Molecular FunctionGO:0004872receptor activityP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:2667237|PMID:12677010
Cellular ComponentGO:0005911cell-cell junctionP2rx7IDAMouseMGI:MGI:3053262|PMID:15331634
Cellular ComponentGO:0009897external side of plasma membraneP2rx7IDAMouseMGI:MGI:3700102|PMID:17286969
Cellular ComponentGO:0005887integral component of plasma membraneP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:2667237|PMID:12677010
Cellular ComponentGO:0005622intracellularP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3772417|PMID:18082965
Cellular ComponentGO:0016020membraneP2RX7IDAHumanPMID:17785580
Cellular ComponentGO:0016020membraneP2rx7IDAMouseMGI:MGI:3529714|PMID:15713258
Cellular ComponentGO:0031594neuromuscular junctionP2rx7IDAMouseMGI:MGI:3529714|PMID:15713258
Cellular ComponentGO:0043025neuronal cell bodyP2rx7IDAMouseMGI:MGI:3583830|PMID:15978588
Cellular ComponentGO:0043025neuronal cell bodyP2rx7IDAMouseMGI:MGI:3610839|PMID:15964665
Cellular ComponentGO:0005886plasma membraneP2rx7IDAMouseMGI:MGI:3053262|PMID:15331634
Cellular ComponentGO:0045202synapseP2rx7IDAMouseMGI:MGI:3772417|PMID:18082965
Biological ProcessGO:0000187activation of MAPK activityP2rx7IMPMouseMGI:MGI:3700006|PMID:17306762
Biological ProcessGO:0032060bleb assemblyP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3706220|PMID:17135244
Biological ProcessGO:0006816calcium ion transportP2rx7IMPMGI:MGI:3042190MouseMGI:MGI:2388453|PMID:12370338
Biological ProcessGO:0006812cation transportP2RX7IDAHumanPMID:9038151
Biological ProcessGO:0006812cation transportP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:2667237|PMID:12677010
Biological ProcessGO:0000902cell morphogenesisP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3653950|PMID:12055263
Biological ProcessGO:0006884cell volume homeostasisP2rx7IDAMouseMGI:MGI:3772554|PMID:18097031
Biological ProcessGO:0031668cellular response to extracellular stimulusP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3772417|PMID:18082965
Biological ProcessGO:0046513ceramide biosynthetic processP2rx7IDAMouseMGI:MGI:3640029|PMID:16325464
Biological ProcessGO:0032963collagen metabolic processP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3796378|PMID:16969386
Biological ProcessGO:0019835cytolysisP2rx7IMPMGI:MGI:2386080|MGI:MGI:3042190MouseMGI:MGI:3040567|PMID:14761980
Biological ProcessGO:0019835cytolysisP2rx7IDAMouseMGI:MGI:3664807|PMID:16116196
Biological ProcessGO:0019835cytolysisP2rx7IDAMouseMGI:MGI:3772554|PMID:18097031
Biological ProcessGO:0050830defense response to Gram-positive bacteriumP2rx7IMPMGI:MGI:3575425MouseMGI:MGI:3699774|PMID:11544318
Biological ProcessGO:0097191extrinsic apoptotic signaling pathwayP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3700102|PMID:17286969
Biological ProcessGO:0010467gene expressionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3797675|PMID:18519738
Biological ProcessGO:0048873homeostasis of number of cells within a tissueP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3796378|PMID:16969386
Biological ProcessGO:0006954inflammatory responseP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3653950|PMID:12055263
Biological ProcessGO:0006954inflammatory responseP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3796378|PMID:16969386
Biological ProcessGO:0034220ion transmembrane transportP2rx7IMPMouseMGI:MGI:3529714|PMID:15713258
Biological ProcessGO:0006900membrane buddingP2rx7IMPMouseMGI:MGI:3580953|PMID:15905573
Biological ProcessGO:0051899membrane depolarizationP2RX7IDAHumanPMID:9038151
Biological ProcessGO:0006509membrane protein ectodomain proteolysisP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3700102|PMID:17286969
Biological ProcessGO:0007005mitochondrion organizationP2rx7IDAMouseMGI:MGI:3640029|PMID:16325464
Biological ProcessGO:0044254multicellular organismal protein catabolic processP2rx7IDAMouseMGI:MGI:2148354|PMID:11489964
Biological ProcessGO:0043132NAD transportP2rx7IMPMouseMGI:MGI:3757798|PMID:17803959
Biological ProcessGO:0045779negative regulation of bone resorptionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:2667237|PMID:12677010
Biological ProcessGO:0043409negative regulation of MAPK cascadeP2rx7IDAMouseMGI:MGI:2148354|PMID:11489964
Biological ProcessGO:0001845phagolysosome assemblyP2rx7IMPMGI:MGI:3575425MouseMGI:MGI:3699774|PMID:11544318
Biological ProcessGO:0006649phospholipid transfer to membraneP2rx7IMPMGI:MGI:3042190MouseMGI:MGI:2388453|PMID:12370338
Biological ProcessGO:0045332phospholipid translocationP2rx7IDAMouseMGI:MGI:3772554|PMID:18097031
Biological ProcessGO:0007009plasma membrane organizationP2rx7IDAMouseMGI:MGI:3772554|PMID:18097031
Biological ProcessGO:0046931pore complex assemblyP2RX7IDAHumanPMID:9038151
Biological ProcessGO:0046931pore complex assemblyP2rx7IMPMGI:MGI:3042190MouseMGI:MGI:2388453|PMID:12370338
Biological ProcessGO:0046931pore complex assemblyP2rx7IMPMouseMGI:MGI:3589701|PMID:15937334
Biological ProcessGO:0046931pore complex assemblyP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3616954|PMID:16269410
Biological ProcessGO:0043065positive regulation of apoptotic processP2rx7IMPMouseMGI:MGI:3640029|PMID:16325464
Biological ProcessGO:0043065positive regulation of apoptotic processP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3796378|PMID:16969386
Biological ProcessGO:0030501positive regulation of bone mineralizationP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:2667237|PMID:12677010
Biological ProcessGO:0030501positive regulation of bone mineralizationP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3797675|PMID:18519738
Biological ProcessGO:0010524positive regulation of calcium ion transport into cytosolP2RX7IDAHumanPMID:9038151
Biological ProcessGO:0043085positive regulation of catalytic activityP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3040567|PMID:14761980
Biological ProcessGO:0050715positive regulation of cytokine secretionP2rx7IMPMGI:MGI:3606250MouseMGI:MGI:3796019|PMID:18490713
Biological ProcessGO:0014054positive regulation of gamma-aminobutyric acid secretionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3610634|PMID:15640761
Biological ProcessGO:0014049positive regulation of glutamate secretionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3610634|PMID:15640761
Biological ProcessGO:0014049positive regulation of glutamate secretionP2rx7IMPMouseMGI:MGI:3700006|PMID:17306762
Biological ProcessGO:0050717positive regulation of interleukin-1 alpha secretionP2rx7IMPMGI:MGI:3606250MouseMGI:MGI:3796019|PMID:18490713
Biological ProcessGO:0032731positive regulation of interleukin-1 beta productionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:1929334|PMID:11016935
Biological ProcessGO:0050718positive regulation of interleukin-1 beta secretionP2RX7IDAHumanPMID:17036048
Biological ProcessGO:0050718positive regulation of interleukin-1 beta secretionP2RX7IDAHumanPMID:18089587
Biological ProcessGO:0050718positive regulation of interleukin-1 beta secretionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:1929334|PMID:11016935
Biological ProcessGO:0050718positive regulation of interleukin-1 beta secretionP2rx7IMPMouseMGI:MGI:3580953|PMID:15905573
Biological ProcessGO:0050718positive regulation of interleukin-1 beta secretionP2rx7IMPMGI:MGI:3606250MouseMGI:MGI:3796019|PMID:18490713
Biological ProcessGO:0032755positive regulation of interleukin-6 productionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:1929334|PMID:11016935
Biological ProcessGO:0070230positive regulation of lymphocyte apoptotic processP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3769218|PMID:16493071
Biological ProcessGO:0043410positive regulation of MAPK cascadeP2rx7IMPMouseMGI:MGI:3589701|PMID:15937334
Biological ProcessGO:0051901positive regulation of mitochondrial depolarizationP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3607437|PMID:16198349
Biological ProcessGO:0045778positive regulation of ossificationP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3616954|PMID:16269410
Biological ProcessGO:0045778positive regulation of ossificationP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3797675|PMID:18519738
Biological ProcessGO:0032308positive regulation of prostaglandin secretionP2rx7IMPMouseMGI:MGI:3616954|PMID:16269410
Biological ProcessGO:0032308positive regulation of prostaglandin secretionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3616954|PMID:16269410
Biological ProcessGO:0001934positive regulation of protein phosphorylationP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3589701|PMID:15937334
Biological ProcessGO:0001934positive regulation of protein phosphorylationP2rx7IMPMouseMGI:MGI:3710713|PMID:17448897
Biological ProcessGO:0050714positive regulation of protein secretionP2rx7IDAMouseMGI:MGI:3051178|PMID:15240711
Biological ProcessGO:0001916positive regulation of T cell mediated cytotoxicityP2rx7IMPMGI:MGI:3042190MouseMGI:MGI:3040567|PMID:14761980
Biological ProcessGO:0012501programmed cell deathP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3664807|PMID:16116196
Biological ProcessGO:0012501programmed cell deathP2rx7IDAMouseMGI:MGI:3772554|PMID:18097031
Biological ProcessGO:0051259protein oligomerizationP2rx7IDAMouseMGI:MGI:3529714|PMID:15713258
Biological ProcessGO:0006468protein phosphorylationP2rx7IMPMouseMGI:MGI:3700006|PMID:17306762
Biological ProcessGO:0016485protein processingP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:1929334|PMID:11016935
Biological ProcessGO:0035590purinergic nucleotide receptor signaling pathwayP2RX7IDAHumanPMID:9038151
Biological ProcessGO:0072593reactive oxygen species metabolic processP2rx7IMPMouseMGI:MGI:3710713|PMID:17448897
Biological ProcessGO:0051209release of sequestered calcium ion into cytosolP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3772417|PMID:18082965
Biological ProcessGO:0033198response to ATPP2RX7IDAHumanPMID:9038151
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:1929334|PMID:11016935
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3040567|PMID:14761980
Biological ProcessGO:0033198response to ATPP2rx7IDAMouseMGI:MGI:3051178|PMID:15240711
Biological ProcessGO:0033198response to ATPP2rx7IDAMouseMGI:MGI:3529714|PMID:15713258
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3583830|PMID:15978588
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3589701|PMID:15937334
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3607437|PMID:16198349
Biological ProcessGO:0033198response to ATPP2rx7IMPMouseMGI:MGI:3640029|PMID:16325464
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3653950|PMID:12055263
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3664807|PMID:16116196
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:3575425MouseMGI:MGI:3699774|PMID:11544318
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3700102|PMID:17286969
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3706220|PMID:17135244
Biological ProcessGO:0033198response to ATPP2rx7IMPMouseMGI:MGI:3710713|PMID:17448897
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3772417|PMID:18082965
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3772554|PMID:18097031
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:3606250MouseMGI:MGI:3796019|PMID:18490713
Biological ProcessGO:0033198response to ATPP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3797675|PMID:18519738
Biological ProcessGO:0009617response to bacteriumP2rx7IMPMouseMGI:MGI:3575403|PMID:10395640
Biological ProcessGO:0051592response to calcium ionP2rx7IDAMouseMGI:MGI:3051178|PMID:15240711
Biological ProcessGO:0051592response to calcium ionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3583830|PMID:15978588
Biological ProcessGO:0051592response to calcium ionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3772417|PMID:18082965
Biological ProcessGO:0042493response to drugP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3772417|PMID:18082965
Biological ProcessGO:0051602response to electrical stimulusP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3610634|PMID:15640761
Biological ProcessGO:0034405response to fluid shear stressP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3616954|PMID:16269410
Biological ProcessGO:0032496response to lipopolysaccharideP2rx7IDAMouseMGI:MGI:3051178|PMID:15240711
Biological ProcessGO:0032496response to lipopolysaccharideP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3653950|PMID:12055263
Biological ProcessGO:0032496response to lipopolysaccharideP2rx7IMPMouseMGI:MGI:3710713|PMID:17448897
Biological ProcessGO:0009612response to mechanical stimulusP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3616954|PMID:16269410
Biological ProcessGO:0014070response to organic cyclic compoundP2rx7IDAMouseMGI:MGI:3051178|PMID:15240711
Biological ProcessGO:0010033response to organic substanceP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3664807|PMID:16116196
Biological ProcessGO:0010033response to organic substanceP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3700102|PMID:17286969
Biological ProcessGO:0010033response to organic substanceP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3768715|PMID:16455971
Biological ProcessGO:0010043response to zinc ionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3583830|PMID:15978588
Biological ProcessGO:0010043response to zinc ionP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3772417|PMID:18082965
Biological ProcessGO:0019233sensory perception of painP2rx7IMPMouseMGI:MGI:3605949|PMID:15777864
Biological ProcessGO:0048705skeletal system morphogenesisP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3797675|PMID:18519738
Biological ProcessGO:0016079synaptic vesicle exocytosisP2rx7IMPMouseMGI:MGI:3529714|PMID:15713258
Biological ProcessGO:0043029T cell homeostasisP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3664807|PMID:16116196
Biological ProcessGO:0042098T cell proliferationP2rx7IMPMGI:MGI:2386080MouseMGI:MGI:3700581|PMID:15914561

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory