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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
1746

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:1746

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Aug 5 20:57:06 2014.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:1746
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005515protein bindingLRP5IPIUniProtKB:Q9BQB4HumanPMID:15908424
Molecular FunctionGO:0005515protein bindingLRP5IPIUniProtKB:Q6IMN6HumanPMID:18762581
Molecular FunctionGO:0005515protein bindingLrp5IPIUniProtKB:O35625MouseMGI:MGI:3817405|PMID:18632848
Molecular FunctionGO:0005515protein bindingLrp5IPIUniProtKB:P15116|UniProtKB:O35625MouseMGI:MGI:3835914|PMID:19075000
Molecular FunctionGO:0042813Wnt-activated receptor activityLrp5IDAMouseMGI:MGI:2178168|PMID:11956231
Molecular FunctionGO:0017147Wnt-protein bindingLrp5IPIUniProtKB:P04426|UniProtKB:P22724MouseMGI:MGI:2178168|PMID:11956231
Cellular ComponentGO:0005739mitochondrionLrp5IDAMouseMGI:MGI:2682130|PMID:14651853
Cellular ComponentGO:0005886plasma membraneLRP5IDAHumanPMID:17680723
Cellular ComponentGO:0043235receptor complexLRP5IDAHumanPMID:18762581
Biological ProcessGO:0060612adipose tissue developmentLRP5IMPHumanPMID:17680723
Biological ProcessGO:0060033anatomical structure regressionLrp5IMPMGI:MGI:2183279MouseMGI:MGI:3604165|PMID:16163358
Biological ProcessGO:0009952anterior/posterior pattern specificationLrp5IGIMGI:MGI:1298218MouseMGI:MGI:3045836|PMID:15142971
Biological ProcessGO:1902262apoptotic process involved in patterning of blood vesselsLrp5IMPMGI:MGI:2183279MouseMGI:MGI:3604165|PMID:16163358
Biological ProcessGO:0060348bone developmentLrp5IMPMouseMGI:MGI:4835143|PMID:17700537
Biological ProcessGO:0048539bone marrow developmentLRP5IMPHumanPMID:17680723
Biological ProcessGO:0060349bone morphogenesisLRP5IMPHumanPMID:19673927
Biological ProcessGO:0060349bone morphogenesisLRP5IMPHumanPMID:20146170
Biological ProcessGO:0060349bone morphogenesisLRP5IMPHumanPMID:20630166
Biological ProcessGO:0046849bone remodelingLrp5IMPMGI:MGI:2183279MouseMGI:MGI:2178168|PMID:11956231
Biological ProcessGO:0046849bone remodelingLrp5IGIMGI:MGI:1298218MouseMGI:MGI:3653806|PMID:15537447
Biological ProcessGO:0046849bone remodelingLrp5IMPMGI:MGI:3612485MouseMGI:MGI:3694400|PMID:16790443
Biological ProcessGO:0046849bone remodelingLrp5IMPMouseMGI:MGI:3762069|PMID:17627087
Biological ProcessGO:0046849bone remodelingLrp5IMPMouseMGI:MGI:3768210|PMID:15207752
Biological ProcessGO:0046849bone remodelingLrp5IMPMGI:MGI:3530598MouseMGI:MGI:3777913|PMID:17147489
Biological ProcessGO:0046849bone remodelingLrp5IGIMGI:MGI:96274|MGI:MGI:98796MouseMGI:MGI:3836667|PMID:19041748
Biological ProcessGO:0060444branching involved in mammary gland duct morphogenesisLrp5IMPMGI:MGI:3663738MouseMGI:MGI:3692480|PMID:16973609
Biological ProcessGO:0060070canonical Wnt signaling pathwayLRP5IDAHumanPMID:12121999
Biological ProcessGO:0060070canonical Wnt signaling pathwayLRP5IDAHumanPMID:12857724
Biological ProcessGO:0060070canonical Wnt signaling pathwayLRP5IDAHumanPMID:15035989
Biological ProcessGO:0060070canonical Wnt signaling pathwayLRP5IMPHumanPMID:19673927
Biological ProcessGO:0060070canonical Wnt signaling pathwayLrp5IDAMouseMGI:MGI:3045675|PMID:15143170
Biological ProcessGO:0060070canonical Wnt signaling pathwayLrp5IDAMouseMGI:MGI:3621833|PMID:15035989
Biological ProcessGO:0060070canonical Wnt signaling pathwayLrp5IMPMGI:MGI:3663738MouseMGI:MGI:3692480|PMID:16973609
Biological ProcessGO:0042074cell migration involved in gastrulationLrp5IGIMGI:MGI:1298218MouseMGI:MGI:3045836|PMID:15142971
Biological ProcessGO:0060764cell-cell signaling involved in mammary gland developmentLrp5IMPMGI:MGI:3663738MouseMGI:MGI:3692480|PMID:16973609
Biological ProcessGO:0042632cholesterol homeostasisLRP5IMPHumanPMID:18721193
Biological ProcessGO:0042632cholesterol homeostasisLRP5IMPHumanPMID:20146170
Biological ProcessGO:0008203cholesterol metabolic processLrp5IMPMGI:MGI:2448955MouseMGI:MGI:2448205|PMID:12509515
Biological ProcessGO:0042733embryonic digit morphogenesisLrp5IGIMGI:MGI:1298218MouseMGI:MGI:3045836|PMID:15142971
Biological ProcessGO:0035426extracellular matrix-cell signalingLrp5IDAMouseMGI:MGI:3621833|PMID:15035989
Biological ProcessGO:0001702gastrulation with mouth forming secondLrp5IGIMGI:MGI:1298218MouseMGI:MGI:3045836|PMID:15142971
Biological ProcessGO:0006007glucose catabolic processLRP5IMPHumanPMID:19673927
Biological ProcessGO:0035108limb morphogenesisLrp5IGIMGI:MGI:1298218MouseMGI:MGI:3653806|PMID:15537447
Biological ProcessGO:0060603mammary gland duct morphogenesisLrp5IGIMGI:MGI:1298218MouseMGI:MGI:3849913|PMID:19503830
Biological ProcessGO:0045668negative regulation of osteoblast differentiationLRP5IMPHumanPMID:17680723
Biological ProcessGO:0071901negative regulation of protein serine/threonine kinase activityLRP5IMPHumanPMID:19107203
Biological ProcessGO:0002076osteoblast developmentLrp5IMPMGI:MGI:3612485MouseMGI:MGI:3694400|PMID:16790443
Biological ProcessGO:0002076osteoblast developmentLrp5IMPMouseMGI:MGI:4835143|PMID:17700537
Biological ProcessGO:0008284positive regulation of cell proliferationLRP5IDAHumanPMID:9790987
Biological ProcessGO:0045600positive regulation of fat cell differentiationLRP5IMPHumanPMID:17680723
Biological ProcessGO:0002053positive regulation of mesenchymal cell proliferationLRP5IMPHumanPMID:17680723
Biological ProcessGO:0045840positive regulation of mitosisLRP5IDAHumanPMID:9790987
Biological ProcessGO:0033690positive regulation of osteoblast proliferationLrp5IMPMGI:MGI:2183279MouseMGI:MGI:2178168|PMID:11956231
Biological ProcessGO:0051091positive regulation of sequence-specific DNA binding transcription factor activityLrp5IDAMouseMGI:MGI:3621833|PMID:15035989
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterLRP5IDAHumanPMID:12857724
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedLRP5IDAHumanPMID:15035989
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedLRP5IDAHumanPMID:17955262
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedLrp5IDAMouseMGI:MGI:3621833|PMID:15035989
Biological ProcessGO:0042981regulation of apoptotic processLrp5IMPMGI:MGI:2183279MouseMGI:MGI:2178168|PMID:11956231
Biological ProcessGO:0008217regulation of blood pressureLRP5IMPHumanPMID:18721193
Biological ProcessGO:0046850regulation of bone remodelingLrp5IMPMouseMGI:MGI:3654194|PMID:12817748
Biological ProcessGO:0060828regulation of canonical Wnt signaling pathwayLRP5IMPHumanPMID:18044981
Biological ProcessGO:0061178regulation of insulin secretion involved in cellular response to glucose stimulusLrp5IMPMGI:MGI:2448955MouseMGI:MGI:2448205|PMID:12509515
Biological ProcessGO:0060042retina morphogenesis in camera-type eyeLRP5IMPHumanPMID:15346351
Biological ProcessGO:0061299retina vasculature morphogenesis in camera-type eyeLrp5IMPMGI:MGI:2183279MouseMGI:MGI:2178168|PMID:11956231
Biological ProcessGO:0061299retina vasculature morphogenesis in camera-type eyeLrp5IMPMGI:MGI:2183279|MGI:MGI:3774282MouseMGI:MGI:3790936|PMID:18263894
Biological ProcessGO:0061299retina vasculature morphogenesis in camera-type eyeLrp5IGIMGI:MGI:102570|MGI:MGI:108520MouseMGI:MGI:4366716|PMID:19837032
Biological ProcessGO:0061304retinal blood vessel morphogenesisLRP5IMPHumanPMID:15024691
Biological ProcessGO:0061304retinal blood vessel morphogenesisLRP5IMPHumanPMID:15346351
Biological ProcessGO:0035019somatic stem cell maintenanceLrp5IMPMGI:MGI:3663738MouseMGI:MGI:4358817|PMID:19672307
Biological ProcessGO:0001944vasculature developmentLrp5IMPMGI:MGI:2183279MouseMGI:MGI:3604165|PMID:16163358
Biological ProcessGO:0016055Wnt signaling pathwayLRP5IDAHumanPMID:17955262
Biological ProcessGO:0016055Wnt signaling pathwayLrp5IDAMouseMGI:MGI:2178168|PMID:11956231
Biological ProcessGO:0016055Wnt signaling pathwayLrp5IGIMGI:MGI:2136761|MGI:MGI:1196625|MGI:MGI:98961MouseMGI:MGI:3581375|PMID:15923619
Biological ProcessGO:0044332Wnt signaling pathway involved in dorsal/ventral axis specificationLRP5IDAHumanPMID:11029007

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory