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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
1551

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:1551

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Aug 5 20:57:06 2014.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:1551
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0033613activating transcription factor bindingGata4IPIUniProtKB:P61295RatRGD:727369|PMID:11994297
Molecular FunctionGO:0033613activating transcription factor bindingGata4IPIUniProtKB:P61295RatPMID:11994297
Molecular FunctionGO:0003682chromatin bindingGata4IDAMouseMGI:MGI:4950833|PMID:21379568
Molecular FunctionGO:0070410co-SMAD bindingGATA4IPIUniProtKB:P97471HumanPMID:21330551
Molecular FunctionGO:0003677DNA bindingGata4IDAMouseMGI:MGI:67540|PMID:8007990
Molecular FunctionGO:0003677DNA bindingGata4IDAMouseMGI:MGI:1289810|PMID:9738004
Molecular FunctionGO:0003677DNA bindingGata4IDAMouseMGI:MGI:3530679|PMID:15539431
Molecular FunctionGO:0003677DNA bindingGata4IDARatRGD:727369|PMID:11994297
Molecular FunctionGO:0003677DNA bindingGata4IDARatRGD:8553321|PMID:8007990
Molecular FunctionGO:0003677DNA bindingGata4IDARatPMID:11994297
Molecular FunctionGO:0003677DNA bindingGata4IDARatPMID:8007990
Molecular FunctionGO:0001158enhancer sequence-specific DNA bindingGata4IDARatRGD:8554432|PMID:20855530
Molecular FunctionGO:0001158enhancer sequence-specific DNA bindingGata4IDARatPMID:20855530
Molecular FunctionGO:0051525NFAT protein bindingGata4IPIRGD:1310749RatRGD:5687133|PMID:22198280
Molecular FunctionGO:0005515protein bindingGATA4IPIUniProtKB:Q99593HumanPMID:12845333
Molecular FunctionGO:0005515protein bindingGATA4IPIUniProtKB:Q9NQ87HumanPMID:15485867
Molecular FunctionGO:0005515protein bindingGATA4IPIUniProtKB:Q9QUS4HumanPMID:15485867
Molecular FunctionGO:0005515protein bindingGATA4IPIUniProtKB:Q9Y5J3HumanPMID:15485867
Molecular FunctionGO:0005515protein bindingGATA4IPIUniProtKB:Q9DBX7HumanPMID:16199874
Molecular FunctionGO:0005515protein bindingGATA4IPIUniProtKB:Q9QUS4HumanPMID:16199874
Molecular FunctionGO:0005515protein bindingGATA4IPIUniProtKB:Q9WV93HumanPMID:16199874
Molecular FunctionGO:0005515protein bindingGATA4IPIUniProtKB:Q9Y2Y9HumanPMID:17053787
Molecular FunctionGO:0005515protein bindingGATA4IPIUniProtKB:Q13285HumanPMID:21220346
Molecular FunctionGO:0005515protein bindingGATA4IPIUniProtKB:Q8WW38HumanPMID:21220346
Molecular FunctionGO:0005515protein bindingGATA4IPIUniProtKB:P52952HumanPMID:9312027
Molecular FunctionGO:0005515protein bindingGata4IPIUniProtKB:Q925J9MouseMGI:MGI:2158098|PMID:11724781
Molecular FunctionGO:0005515protein bindingGata4IPIUniProtKB:Q6P9Z1MouseMGI:MGI:3511419|PMID:15525990
Molecular FunctionGO:0005515protein bindingGata4IPIUniProtKB:Q62315MouseMGI:MGI:3525051|PMID:15542826
Molecular FunctionGO:0005515protein bindingGata4IPIUniProtKB:Q9QUS4MouseMGI:MGI:3624193|PMID:16603706
Molecular FunctionGO:0005515protein bindingGata4IPIUniProtKB:P42582|UniProtKB:Q99593MouseMGI:MGI:3687882|PMID:12845333
Molecular FunctionGO:0005515protein bindingGata4IPIUniProtKB:Q9EPZ6MouseMGI:MGI:3722519|PMID:17584735
Molecular FunctionGO:0005515protein bindingGata4IPIUniProtKB:P70168MouseMGI:MGI:3722541|PMID:17548362
Molecular FunctionGO:0005515protein bindingGata4IPIUniProtKB:P70288MouseMGI:MGI:4831050|PMID:20833366
Molecular FunctionGO:0005515protein bindingGata4IPIUniProtKB:P42582MouseMGI:MGI:4839464|PMID:9584153
Molecular FunctionGO:0005515protein bindingGata4IPIUniProtKB:Q9ES03MouseMGI:MGI:5284807|PMID:14550786
Molecular FunctionGO:0005515protein bindingGata4IPIUniProtKB:P79457MouseMGI:MGI:5305502|PMID:22192413
Molecular FunctionGO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingGata4IDAMouseMGI:MGI:5487528|PMID:21029371
Molecular FunctionGO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGata4IDAMouseMGI:MGI:3763665|PMID:17975667
Molecular FunctionGO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGata4IDAMouseMGI:MGI:4950833|PMID:21379568
Molecular FunctionGO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingGata4IDAMouseMGI:MGI:3624193|PMID:16603706
Molecular FunctionGO:0001076RNA polymerase II transcription factor binding transcription factor activityGATA4IDAHumanPMID:21330551
Molecular FunctionGO:0001076RNA polymerase II transcription factor binding transcription factor activityGata4IDAMouseMGI:MGI:3687882|PMID:12845333
Molecular FunctionGO:0043565sequence-specific DNA bindingGata4IDAMouseMGI:MGI:53125|PMID:8455608
Molecular FunctionGO:0043565sequence-specific DNA bindingGata4IDAMouseMGI:MGI:81843|PMID:8754853
Molecular FunctionGO:0043565sequence-specific DNA bindingGata4IMPRatRGD:1580391|PMID:12704188
Molecular FunctionGO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activityGata4IDAMouseMGI:MGI:3624193|PMID:16603706
Molecular FunctionGO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activityGata4IDAMouseMGI:MGI:3722541|PMID:17548362
Molecular FunctionGO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activityGata4IDAMouseMGI:MGI:5487528|PMID:21029371
Molecular FunctionGO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activityGata4IDARatRGD:5131533|PMID:20384792
Molecular FunctionGO:0003700sequence-specific DNA binding transcription factor activityGATA4IDAHumanPMID:9312027
Molecular FunctionGO:0003700sequence-specific DNA binding transcription factor activityGata4IDAMouseMGI:MGI:1289810|PMID:9738004
Molecular FunctionGO:0003700sequence-specific DNA binding transcription factor activityGata4IDAMouseMGI:MGI:3047455|PMID:15082719
Molecular FunctionGO:0003700sequence-specific DNA binding transcription factor activityGata4IDARatRGD:727369|PMID:11994297
Molecular FunctionGO:0003700sequence-specific DNA binding transcription factor activityGata4IDARatPMID:11994297
Molecular FunctionGO:0003713transcription coactivator activityGATA4IDAHumanPMID:21220346
Molecular FunctionGO:0008134transcription factor bindingGATA4IPIUniProtKB:P52952HumanPMID:9858576
Molecular FunctionGO:0008134transcription factor bindingGata4IPIRGD:620036RatRGD:2312265|PMID:18292809
Molecular FunctionGO:0008134transcription factor bindingGata4IDARatRGD:727369|PMID:11994297
Molecular FunctionGO:0008134transcription factor bindingGata4IPIUniProtKB:P46153RatRGD:8553656|PMID:10330176
Molecular FunctionGO:0008134transcription factor bindingGata4IPIUniProtKB:P46153RatPMID:10330176
Molecular FunctionGO:0044212transcription regulatory region DNA bindingGATA4IDAHumanPMID:21220346
Molecular FunctionGO:0044212transcription regulatory region DNA bindingGATA4IDAHumanPMID:9566909
Molecular FunctionGO:0044212transcription regulatory region DNA bindingGata4IDARatRGD:8554170|PMID:12606287
Molecular FunctionGO:0044212transcription regulatory region DNA bindingGata4IDARatPMID:12606287
Cellular ComponentGO:0000790nuclear chromatinGata4IDAMouseMGI:MGI:5487528|PMID:21029371
Cellular ComponentGO:0005634nucleusGATA4IDAHumanPMID:21220346
Cellular ComponentGO:0005634nucleusGATA4IDAHumanPMID:9566909
Cellular ComponentGO:0005634nucleusGata4IDAMouseMGI:MGI:2675862|PMID:12801993
Cellular ComponentGO:0005634nucleusGata4IDAMouseMGI:MGI:3696911|PMID:16940177
Cellular ComponentGO:0005634nucleusGata4IDAMouseMGI:MGI:3722541|PMID:17548362
Cellular ComponentGO:0005634nucleusGata4IDAMouseMGI:MGI:3763665|PMID:17975667
Cellular ComponentGO:0005634nucleusGata4IDAMouseMGI:MGI:4422111|PMID:20123909
Cellular ComponentGO:0005634nucleusGata4IDAMouseMGI:MGI:4887500|PMID:21220346
Cellular ComponentGO:0005634nucleusGata4IDAMouseMGI:MGI:4946462|PMID:21146513
Cellular ComponentGO:0005634nucleusGata4IDARatRGD:1580391|PMID:12704188
Biological ProcessGO:0060413atrial septum morphogenesisGATA4IMPHumanPMID:12845333
Biological ProcessGO:0003289atrial septum primum morphogenesisGata4IMPMouseMGI:MGI:3769320|PMID:17643447
Biological ProcessGO:0003290atrial septum secundum morphogenesisGATA4IMPHumanPMID:20347099
Biological ProcessGO:0036302atrioventricular canal developmentGata4IGIUniProtKB:P97471MouseMGI:MGI:4946551|PMID:21330551
Biological ProcessGO:0003190atrioventricular valve formationGata4IGIUniProtKB:P97471MouseMGI:MGI:4946551|PMID:21330551
Biological ProcessGO:0003181atrioventricular valve morphogenesisGata4IGIMGI:MGI:102541MouseMGI:MGI:3833786|PMID:19084512
Biological ProcessGO:0030509BMP signaling pathwayGata4IDAMouseMGI:MGI:3703823|PMID:17360443
Biological ProcessGO:0060070canonical Wnt signaling pathwayGata4IDAMouseMGI:MGI:3703823|PMID:17360443
Biological ProcessGO:0055007cardiac muscle cell differentiationGata4IGIMGI:MGI:107516MouseMGI:MGI:3790568|PMID:18400219
Biological ProcessGO:0055007cardiac muscle cell differentiationGata4IMPMGI:MGI:3793424MouseMGI:MGI:3790568|PMID:18400219
Biological ProcessGO:0055007cardiac muscle cell differentiationGata4IGIMGI:MGI:102541|MGI:MGI:99458MouseMGI:MGI:4881377|PMID:20691899
Biological ProcessGO:0014898cardiac muscle hypertrophy in response to stressGata4IMPMGI:MGI:3778685|MGI:MGI:3054171MouseMGI:MGI:5002493|PMID:20705924
Biological ProcessGO:0048738cardiac muscle tissue developmentGata4IGIMGI:MGI:107516MouseMGI:MGI:5002493|PMID:20705924
Biological ProcessGO:0003215cardiac right ventricle morphogenesisGata4IMPMouseMGI:MGI:3769320|PMID:17643447
Biological ProcessGO:0003279cardiac septum developmentGata4IGIUniProtKB:P97471MouseMGI:MGI:4946551|PMID:21330551
Biological ProcessGO:0061049cell growth involved in cardiac muscle cell developmentGata4IDARatRGD:5131529|PMID:20971938
Biological ProcessGO:0007267cell-cell signalingGata4IMPMGI:MGI:2386764MouseMGI:MGI:3590399|PMID:16127717
Biological ProcessGO:0071372cellular response to follicle-stimulating hormone stimulusGata4IDAMouseMGI:MGI:1095695|PMID:9231805
Biological ProcessGO:0071371cellular response to gonadotropin stimulusGata4IDAMouseMGI:MGI:1095695|PMID:9231805
Biological ProcessGO:0048557embryonic digestive tract morphogenesisGata4IMPMGI:MGI:2386764MouseMGI:MGI:3590399|PMID:16127717
Biological ProcessGO:0048617embryonic foregut morphogenesisGata4IMPMGI:MGI:2386265MouseMGI:MGI:87488|PMID:9136932
Biological ProcessGO:0048617embryonic foregut morphogenesisGata4IMPMGI:MGI:2179443MouseMGI:MGI:87489|PMID:9136933
Biological ProcessGO:0035054embryonic heart tube anterior/posterior pattern specificationGata4IMPMGI:MGI:2386265MouseMGI:MGI:87488|PMID:9136932
Biological ProcessGO:0035050embryonic heart tube developmentGata4IMPMGI:MGI:2386265MouseMGI:MGI:87488|PMID:9136932
Biological ProcessGO:0035050embryonic heart tube developmentGata4IMPMGI:MGI:2179443MouseMGI:MGI:87489|PMID:9136933
Biological ProcessGO:0048598embryonic morphogenesisGata4IMPMGI:MGI:2386265MouseMGI:MGI:87488|PMID:9136932
Biological ProcessGO:0048598embryonic morphogenesisGata4IMPMGI:MGI:2179443MouseMGI:MGI:87489|PMID:9136933
Biological ProcessGO:0003197endocardial cushion developmentGATA4IMPHumanPMID:21330551
Biological ProcessGO:0003197endocardial cushion developmentGata4IMPMouseMGI:MGI:3769320|PMID:17643447
Biological ProcessGO:0003197endocardial cushion developmentGata4IGIMGI:MGI:102541MouseMGI:MGI:3833786|PMID:19084512
Biological ProcessGO:0001706endoderm formationGata4IMPMGI:MGI:2179511MouseMGI:MGI:77407|PMID:8582296
Biological ProcessGO:0072148epithelial cell fate commitmentGata4IMPMGI:MGI:3526854|MGI:MGI:3053826MouseMGI:MGI:3696911|PMID:16940177
Biological ProcessGO:0001702gastrulation with mouth forming secondGata4IMPMGI:MGI:2179443MouseMGI:MGI:87489|PMID:9136933
Biological ProcessGO:0007507heart developmentGata4IMPMGI:MGI:2386764MouseMGI:MGI:2181523|PMID:11297508
Biological ProcessGO:0007507heart developmentGata4IMPMGI:MGI:3526854|MGI:MGI:3526856|MGI:MGI:3526853MouseMGI:MGI:3513631|PMID:15464586
Biological ProcessGO:0001947heart loopingGata4IMPMouseMGI:MGI:3052615|PMID:15310850
Biological ProcessGO:0003007heart morphogenesisGata4IMPMouseMGI:MGI:3763665|PMID:17975667
Biological ProcessGO:0001701in utero embryonic developmentGata4IMPMGI:MGI:2386265MouseMGI:MGI:87488|PMID:9136932
Biological ProcessGO:0001701in utero embryonic developmentGata4IMPMGI:MGI:2179443MouseMGI:MGI:87489|PMID:9136933
Biological ProcessGO:0001701in utero embryonic developmentGata4IMPMGI:MGI:3033220MouseMGI:MGI:3052615|PMID:15310850
Biological ProcessGO:0001701in utero embryonic developmentGata4IMPMGI:MGI:3793424MouseMGI:MGI:4422111|PMID:20123909
Biological ProcessGO:0060575intestinal epithelial cell differentiationGATA4IDAHumanPMID:9566909
Biological ProcessGO:0060464lung lobe formationGata4IMPMGI:MGI:2386764MouseMGI:MGI:3784878|PMID:17142311
Biological ProcessGO:0008584male gonad developmentGATA4IMPHumanPMID:21220346
Biological ProcessGO:0010507negative regulation of autophagyGata4IMPRatRGD:5131537|PMID:19901028
Biological ProcessGO:0045766positive regulation of angiogenesisGata4IDAMouseMGI:MGI:3763665|PMID:17975667
Biological ProcessGO:0030513positive regulation of BMP signaling pathwayGata4IDARatRGD:8554170|PMID:12606287
Biological ProcessGO:0030513positive regulation of BMP signaling pathwayGata4IDARatPMID:12606287
Biological ProcessGO:0060045positive regulation of cardiac muscle cell proliferationGata4IGIMGI:MGI:102541MouseMGI:MGI:3833786|PMID:19084512
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGATA4IDAHumanPMID:21330551
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:53125|PMID:8455608
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:67540|PMID:8007990
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:3530679|PMID:15539431
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IGIMGI:MGI:1347472|MGI:MGI:1347476MouseMGI:MGI:3530679|PMID:15539431
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IGIMGI:MGI:1334444|MGI:MGI:98214MouseMGI:MGI:3577779|PMID:15766748
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:3614736|PMID:16380715
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IMPMGI:MGI:3526856MouseMGI:MGI:3714902|PMID:17272516
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:3722541|PMID:17548362
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IMPMouseMGI:MGI:3828404|PMID:16137232
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IMPMouseMGI:MGI:4887500|PMID:21220346
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:5487528|PMID:21029371
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterGata4IDARatRGD:727369|PMID:11994297
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedGata4IDAMouseMGI:MGI:3040553|PMID:14978031
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedGata4IDAMouseMGI:MGI:3687882|PMID:12845333
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedGata4IDAMouseMGI:MGI:3763665|PMID:17975667
Biological ProcessGO:0010575positive regulation vascular endothelial growth factor productionGata4IDAMouseMGI:MGI:3763665|PMID:17975667
Biological ProcessGO:0086004regulation of cardiac muscle cell contractionGata4IMPRatRGD:7207043|PMID:21702924
Biological ProcessGO:0060043regulation of cardiac muscle cell proliferationGata4IMPMGI:MGI:3526854MouseMGI:MGI:3581473|PMID:15902305
Biological ProcessGO:0010468regulation of gene expressionGata4IGIMGI:MGI:107516MouseMGI:MGI:3790568|PMID:18400219
Biological ProcessGO:0010468regulation of gene expressionGata4IDAMouseMGI:MGI:4831050|PMID:20833366
Biological ProcessGO:0006357regulation of transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:53125|PMID:8455608
Biological ProcessGO:0006357regulation of transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:67540|PMID:8007990
Biological ProcessGO:0006357regulation of transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:2653650|PMID:12606418
Biological ProcessGO:0006357regulation of transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:3040553|PMID:14978031
Biological ProcessGO:0006357regulation of transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:3047455|PMID:15082719
Biological ProcessGO:0006355regulation of transcription, DNA-templatedGata4IDAMouseMGI:MGI:1289810|PMID:9738004
Biological ProcessGO:0006355regulation of transcription, DNA-templatedGata4IDARatRGD:625524|PMID:11827958
Biological ProcessGO:0042493response to drugGATA4IMPHumanPMID:20585342
Biological ProcessGO:0043627response to estrogenGata4IDAMouseMGI:MGI:1095695|PMID:9231805
Biological ProcessGO:0009612response to mechanical stimulusGata4IDARatRGD:5131528|PMID:21084678
Biological ProcessGO:0032526response to retinoic acidGata4IDAMouseMGI:MGI:3799604|PMID:18439490
Biological ProcessGO:0072520seminiferous tubule developmentGata4IMPMGI:MGI:3778685|MGI:MGI:3042214MouseMGI:MGI:4939548|PMID:21172404
Biological ProcessGO:0060008Sertoli cell differentiationGata4IMPMGI:MGI:3778685|MGI:MGI:3042214MouseMGI:MGI:4939548|PMID:21172404
Biological ProcessGO:0023019signal transduction involved in regulation of gene expressionGata4IDAMouseMGI:MGI:4415813|PMID:18462699
Biological ProcessGO:0060395SMAD protein signal transductionGata4IDAMouseMGI:MGI:1195384|PMID:9420335
Biological ProcessGO:0007283spermatogenesisGata4IMPMGI:MGI:3778685|MGI:MGI:3042214MouseMGI:MGI:4939548|PMID:21172404
Biological ProcessGO:0006366transcription from RNA polymerase II promoterGata4IDAMouseMGI:MGI:3687882|PMID:12845333
Biological ProcessGO:0060290transdifferentiationGata4IMPRatRGD:7327215|PMID:23948075
Biological ProcessGO:0035239tube morphogenesisGata4IGIMGI:MGI:107516MouseMGI:MGI:3790568|PMID:18400219
Biological ProcessGO:0003229ventricular cardiac muscle tissue developmentGata4IGIMGI:MGI:102541MouseMGI:MGI:3833786|PMID:19084512
Biological ProcessGO:0003281ventricular septum developmentGata4IMPMouseMGI:MGI:3769320|PMID:17643447

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory