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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human SPAST HGNC:11233 (HGNC)
6683 (Entrez Gene)
604277 (OMIM)
Spastin (MyGene.info)
HGNC homology
Chr2 p22.3 Chr2:32063551-32157637 (+)
hereditary spastic paraplegia 4
Q9UBP0 (UniProt | EBI)
NM_001363875 (RefSeq)
mouse Spast MGI:1858896 (MGI)
50850 (Entrez Gene)
Gene Tree
HGNC homology
Chr17 45.64 cM Chr17:74338987-74391115 (+)
hereditary spastic paraplegia 4
ENSMUSG00000024068 (Ensembl Gene Model)
ENSMUSP00000024869 (Ensembl)
ENSMUST00000024869 (Ensembl)
rat Spast 362700 (Entrez Gene)
Chr6 q13 B2RYN7 (UniProt | EBI)
NM_001108702 (RefSeq)
chimpanzee SPAST 459133 (Entrez Gene)
Chr2A XP_515388 (RefSeq)
cattle SPAST 521442 (Entrez Gene)
Chr11 A2VDN5 (UniProt | EBI)
NM_001081591 (RefSeq)
dog SPAST 608582 (Entrez Gene)
Chr17 XP_862831 (RefSeq)
chicken SPAST 421481 (Entrez Gene)
Chr3 Q5ZK92 (UniProt | EBI)
NM_001031061 (RefSeq)
zebrafish spast 405851 (Entrez Gene)
Chr1 Q6NW58 (UniProt | EBI)
NM_212915 (RefSeq)
frog, western clawed spast 549207 (Entrez Gene)
Chr5 Q05AS3 (UniProt | EBI)
NM_001016453 (RefSeq)
macaque, rhesus SPAST 706264 (Entrez Gene)
Chr13 XP_014967546 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory