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Vertebrate Homology Class
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human SPAST HGNC:11233 (HGNC)
6683 (Entrez Gene)
604277 (OMIM)
Chr2 p24-p21 Chr2:32063592-32157637 (+)
Spastic Paraplegia 4, Autosomal Dominant; SPG4
Q9UBP0 (UniProt | EBI)
NM_014946 (RefSeq)
mouse Spast MGI:1858896 (MGI)
50850 (Entrez Gene)
Gene Tree
Chr17 45.64 cM Chr17:74338987-74391113 (+)
Spastic Paraplegia 4, Autosomal Dominant; SPG4
ENSMUSG00000024068 (Ensembl Gene Model)
ENSMUSP00000024869 (Ensembl)
ENSMUST00000024869 (Ensembl)
rat Spast 362700 (Entrez Gene)
Chr6 q12 B2RYN7 (UniProt | EBI)
NM_001108702 (RefSeq)
chimpanzee SPAST 459133 (Entrez Gene)
Chr2A XP_001164367 (RefSeq)
rhesus macaque SPAST 706264 (Entrez Gene)
Chr13 XP_002799248 (RefSeq)
cattle SPAST 521442 (Entrez Gene)
Chr11 A2VDN5 (UniProt | EBI)
NM_001081591 (RefSeq)
dog SPAST 608582 (Entrez Gene)
Chr17 XP_850973 (RefSeq)
chicken SPAST 421481 (Entrez Gene)
Chr3 Q5ZK92 (UniProt | EBI)
NM_001031061 (RefSeq)
western clawed frog spast 549207 (Entrez Gene)
ChrUN Q05AS3 (UniProt | EBI)
NM_001016453 (RefSeq)
zebrafish spast 405851 (Entrez Gene)
Chr1 Q6NW58 (UniProt | EBI)
NM_212915 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory