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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human HFE HGNC:4886 (HGNC)
3077 (Entrez Gene)
613609 (OMIM)
HGNC homology
Chr6 p21.3 Chr6:26087281-26096117 (+)
Alzheimer Disease; AD
Hemochromatosis, Type 1; HFE1
Microvascular Complications of Diabetes, Susceptibility to, 7; MVCD7
Porphyria Cutanea Tarda
Porphyria Variegata
Q30201 (UniProt | EBI)
NM_139011 (RefSeq)
mouse Hfe MGI:109191 (MGI)
15216 (Entrez Gene)
Gene Tree
Chr13 9.88 cM Chr13:23702034-23710854 (-)
Hemochromatosis, Type 1; HFE1
OTTMUSG00000000737 (VEGA)
OTTMUSP00000000659 (VEGA)
OTTMUST00000001384 (VEGA)
rat Hfe 29199 (Entrez Gene)
Chr17 p11-q11 O35799 (UniProt | EBI)
NM_053301 (RefSeq)
chimpanzee HFE 462489 (Entrez Gene)
Chr6 P60018 (UniProt | EBI)
NM_001009101 (RefSeq)
rhesus macaque HFE 696129 (Entrez Gene)
Chr4 NP_001247505 (RefSeq)
NM_001260576 (RefSeq)
cattle HFE 497622 (Entrez Gene)
Chr23 NP_001012399 (RefSeq)
NM_001012399 (RefSeq)
dog HFE 100688951 (Entrez Gene)
Chr35 XP_005640153 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory