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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human SIRT3 HGNC:14931 (HGNC)
23410 (Entrez Gene)
604481 (OMIM)
SIRT3 (MyGene.info)
HGNC homology
Chr11 p15.5 Chr11:215030-236950 (-)
Q9NTG7 (UniProt | EBI)
NM_012239 (RefSeq)
mouse Sirt3 MGI:1927665 (MGI)
64384 (Entrez Gene)
Gene Tree
HGNC homology
Chr7 86.07 cM Chr7:140863666-140882309 (-)
abdominal obesity-metabolic syndrome
OTTMUSG00000023441 (VEGA)
OTTMUSP00000076858 (VEGA)
OTTMUST00000147733 (VEGA)
rat Sirt3 293615 (Entrez Gene)
Chr1 q41 NP_001099783 (RefSeq)
NM_001106313 (RefSeq)
chimpanzee SIRT3 450911 (Entrez Gene)
Chr11 XP_016775429 (RefSeq)
cattle SIRT3 614027 (Entrez Gene)
Chr11 NP_001193598 (RefSeq)
NM_001206669 (RefSeq)
dog SIRT3 475933 (Entrez Gene)
Chr18 XP_013976512 (RefSeq)
chicken SIRT3 422988 (Entrez Gene)
Chr5 NP_001186422 (RefSeq)
NM_001199493 (RefSeq)
zebrafish sirt3 558775 (Entrez Gene)
Chr7 NP_001073643 (RefSeq)
NM_001080174 (RefSeq)
frog, western clawed sirt3.1 100487410 (Entrez Gene)
Chr4 XP_012817602 (RefSeq)
macaque, rhesus SIRT3 720737 (Entrez Gene)
Chr14 XP_014968685 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory