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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human ICOS HGNC:5351 (HGNC)
29851 (Entrez Gene)
604558 (OMIM)
HGNC homology
Chr2 q33.2 Chr2:203936731-203961579 (+)
Immunodeficiency, Common Variable, 1; CVID1
Immunodeficiency, Common Variable, 2; CVID2
Q9Y6W8 (UniProt | EBI)
NM_012092 (RefSeq)
mouse Icos MGI:1858745 (MGI)
54167 (Entrez Gene)
Gene Tree
HGNC homology
Chr1 30.6 cM Chr1:60977927-61000320 (+)
Immunodeficiency, Common Variable, 1; CVID1
OTTMUSG00000002307 (VEGA)
OTTMUSP00000002207 (VEGA)
OTTMUST00000004596 (VEGA)
rat Icos 64545 (Entrez Gene)
Chr9 Q9R1T7 (UniProt | EBI)
NM_022610 (RefSeq)
chimpanzee ICOS 747295 (Entrez Gene)
Chr2B XP_001173460 (RefSeq)
cattle ICOS 507026 (Entrez Gene)
Chr2 Q58DF9 (UniProt | EBI)
NM_001034275 (RefSeq)
dog ICOS 403456 (Entrez Gene)
Chr37 Q7YR73 (UniProt | EBI)
NM_001002972 (RefSeq)
macaque, rhesus ICOS 705788 (Entrez Gene)
Chr12 NP_001253918 (RefSeq)
NM_001266989 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory