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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human NOTCH2 HGNC:7882 (HGNC)
4853 (Entrez Gene)
600275 (OMIM)
HGNC homology
Chr1 p13-p11 Chr1:119911553-120069703 (-)
Alagille Syndrome 2; ALGS2
Hajdu-Cheney Syndrome; HJCYS
Q04721 (UniProt | EBI)
NM_024408 (RefSeq)
mouse Notch2 MGI:97364 (MGI)
18129 (Entrez Gene)
Gene Tree
Chr3 42.42 cM Chr3:98013527-98150361 (+)
Preeclampsia/Eclampsia 1; PEE1
OTTMUSG00000053240 (VEGA)
OTTMUSP00000070816 (VEGA)
OTTMUST00000132998 (VEGA)
rat Notch2 29492 (Entrez Gene)
Chr2 q34 Q9QW30 (UniProt | EBI)
NM_024358 (RefSeq)
chimpanzee NOTCH2 457173 (Entrez Gene)
Chr1 XP_513697 (RefSeq)
rhesus macaque NOTCH2 713798 (Entrez Gene)
Chr1 NP_001247591 (RefSeq)
NM_001260662 (RefSeq)
cattle NOTCH2 513730 (Entrez Gene)
Chr3 XP_015318928 (RefSeq)
dog NOTCH2 483148 (Entrez Gene)
Chr17 XP_005630745 (RefSeq)
chicken NOTCH2 374031 (Entrez Gene)
Chr8 NP_001238962 (RefSeq)
NM_001252033 (RefSeq)
western clawed frog notch2 100486344 (Entrez Gene)
ChrUN XP_002939126 (RefSeq)
zebrafish notch2 58065 (Entrez Gene)
Chr8 NP_001108566 (RefSeq)
NM_001115094 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory