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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human CASP8 HGNC:1509 (HGNC)
841 (Entrez Gene)
601763 (OMIM)
HGNC homology
Chr2 q33-q34 Chr2:201233443-201287711 (+)
Breast Cancer
CASPase 8 Deficiency
Hepatocellular Carcinoma
Lung Cancer
Q14790 (UniProt | EBI)
NM_033356 (RefSeq)
mouse Casp8 MGI:1261423 (MGI)
12370 (Entrez Gene)
Gene Tree
HGNC homology
Chr1 29.19 cM Chr1:58795374-58847503 (+)
CASPase 8 Deficiency
Dermatitis, Atopic
OTTMUSG00000047216 (VEGA)
OTTMUSP00000067072 (VEGA)
OTTMUST00000122094 (VEGA)
rat Casp8 64044 (Entrez Gene)
Chr9 q31 Q9JHX4 (UniProt | EBI)
NM_022277 (RefSeq)
chimpanzee CASP8 746477 (Entrez Gene)
Chr2B XP_009442269 (RefSeq)
rhesus macaque CASP8 702781 (Entrez Gene)
Chr12 XP_014966132 (RefSeq)
cattle CASP8 507481 (Entrez Gene)
Chr2 NP_001039435 (RefSeq)
NM_001045970 (RefSeq)
dog CASP8 488473 (Entrez Gene)
Chr37 NP_001041494 (RefSeq)
NM_001048029 (RefSeq)
chicken CASP8 395284 (Entrez Gene)
Chr7 NP_989923 (RefSeq)
NM_204592 (RefSeq)
western clawed frog casp8 100495471 (Entrez Gene)
ChrUN XP_012826882 (RefSeq)
zebrafish casp8 58022 (Entrez Gene)
Chr6 NP_571585 (RefSeq)
NM_131510 (RefSeq)
casp8l1 100049706 (Entrez Gene)
Chr6 NP_001092089 (RefSeq)
NM_001098619 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory