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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human PSEN1 HGNC:9508 (HGNC)
5663 (Entrez Gene)
104311 (OMIM)
HGNC homology
Chr14 q24.3 Chr14:73136435-73223691 (+)
Acne Inversa, Familial, 3; ACNINV3
Alzheimer Disease 3
Cardiomyopathy, Dilated, 1u; CMD1U
Frontotemporal Dementia; FTD
Pick Disease of Brain
P49768 (UniProt | EBI)
NM_007319 (RefSeq)
mouse Psen1 MGI:1202717 (MGI)
19164 (Entrez Gene)
Gene Tree
HGNC homology
Chr12 38.84 cM Chr12:83688203-83735199 (+)
Alzheimer Disease 3
Alzheimer Disease; AD
ENSMUSG00000019969 (Ensembl Gene Model)
ENSMUSP00000048363 (Ensembl)
ENSMUST00000041806 (Ensembl)
rat Psen1 29192 (Entrez Gene)
Chr6 q31 P97887 (UniProt | EBI)
NM_019163 (RefSeq)
chimpanzee PSEN1 739740 (Entrez Gene)
Chr14 XP_001150037 (RefSeq)
rhesus macaque PSEN1 696274 (Entrez Gene)
Chr7 NP_001253409 (RefSeq)
NM_001266480 (RefSeq)
cattle PSEN1 282705 (Entrez Gene)
Chr10 Q9XT97 (UniProt | EBI)
NM_174721 (RefSeq)
dog PSEN1 403408 (Entrez Gene)
Chr8 Q6RH31 (UniProt | EBI)
NM_001002943 (RefSeq)
chicken PSEN1 373977 (Entrez Gene)
Chr5 Q4JIM4 (UniProt | EBI)
NM_204163 (RefSeq)
western clawed frog psen1 394924 (Entrez Gene)
ChrUN NP_001027027 (RefSeq)
NM_001031856 (RefSeq)
zebrafish psen1 30221 (Entrez Gene)
Chr17 Q9W6T7 (UniProt | EBI)
NM_131024 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory