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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human SIRT1 HGNC:14929 (HGNC)
23411 (Entrez Gene)
604479 (OMIM)
Sirtuin 1 (MyGene.info)
HGNC homology
Chr10 q21.3 Chr10:67884669-67918390 (+)
Q96EB6 (UniProt | EBI)
NM_001314049 (RefSeq)
mouse Sirt1 MGI:2135607 (MGI)
93759 (Entrez Gene)
Gene Tree
HGNC homology
Chr10 32.57 cM Chr10:63319005-63381704 (-)
fatty liver disease
nephrogenic diabetes insipidus
OTTMUSG00000030914 (VEGA)
OTTMUSP00000040277 (VEGA)
OTTMUST00000076493 (VEGA)
rat Sirt1 309757 (Entrez Gene)
Chr20 p11 A0A0G2JZ79 (UniProt | EBI)
NM_001107627 (RefSeq)
chimpanzee SIRT1 466088 (Entrez Gene)
cattle SIRT1 613629 (Entrez Gene)
Chr28 NP_001179909 (RefSeq)
NM_001192980 (RefSeq)
dog SIRT1 489012 (Entrez Gene)
Chr4 XP_022273181 (RefSeq)
chicken SIRT1 423646 (Entrez Gene)
Chr6 NP_001004767 (RefSeq)
NM_001004767 (RefSeq)
zebrafish sirt1 797132 (Entrez Gene)
Chr13 XP_001334440 (RefSeq)
frog, western clawed sirt1 100145679 (Entrez Gene)
Chr7 NP_001136381 (RefSeq)
NM_001142909 (RefSeq)
macaque, rhesus SIRT1 695682 (Entrez Gene)
Chr9 XP_015003003 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory