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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human DES HGNC:2770 (HGNC)
1674 (Entrez Gene)
125660 (OMIM)
Desmin (MyGene.info)
HGNC homology
Chr2 q35 Chr2:219418377-219426739 (+)
autosomal recessive limb-girdle muscular dystrophy type 2R
dilated cardiomyopathy 1I
myofibrillar myopathy 1
P17661 (UniProt | EBI)
NM_001927 (RefSeq)
mouse Des MGI:94885 (MGI)
13346 (Entrez Gene)
Gene Tree
HGNC homology
Chr1 38.85 cM Chr1:75360329-75368579 (+)
dilated cardiomyopathy 1I
myofibrillar myopathy 1
OTTMUSG00000019416 (VEGA)
OTTMUSP00000020924 (VEGA)
OTTMUST00000046346 (VEGA)
rat Des 64362 (Entrez Gene)
Chr9 q33 P48675 (UniProt | EBI)
NM_022531 (RefSeq)
chimpanzee DES 470657 (Entrez Gene)
Chr2B XP_526039 (RefSeq)
cattle DES 280765 (Entrez Gene)
Chr2 O62654 (UniProt | EBI)
NM_001081575 (RefSeq)
dog DES 497091 (Entrez Gene)
Chr37 Q5XFN2 (UniProt | EBI)
NM_001012394 (RefSeq)
chicken DES 395906 (Entrez Gene)
Chr7 P02542 (UniProt | EBI)
frog, western clawed des.1 394739 (Entrez Gene)
Chr9 NP_989134 (RefSeq)
NM_203803 (RefSeq)
macaque, rhesus DES 703300 (Entrez Gene)
Chr12 NP_001181195 (RefSeq)
NM_001194266 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory