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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human APP HGNC:620 (HGNC)
351 (Entrez Gene)
104760 (OMIM)
Amyloid precursor protein (MyGene.info)
HGNC homology
Chr21 q21.3 Chr21:25880550-26171128 (-)
Alzheimer's disease
APP-related cerebral amyloid angiopathy
P05067 (UniProt | EBI)
NM_001204303 (RefSeq)
mouse App MGI:88059 (MGI)
11820 (Entrez Gene)
Gene Tree
HGNC homology
Chr16 46.92 cM Chr16:84952666-85173952 (-)
Alzheimer's disease
11820 (NCBI Gene Model)
P12023 (UniProt | EBI)
NM_001198823 (RefSeq)
rat App 54226 (Entrez Gene)
Chr11 q11 P08592 (UniProt | EBI)
NM_019288 (RefSeq)
chimpanzee APP 473931 (Entrez Gene)
Chr21 Q5IS80 (UniProt | EBI)
NM_001013018 (RefSeq)
cattle APP 280722 (Entrez Gene)
Chr1 Q28053 (UniProt | EBI)
NM_001076796 (RefSeq)
dog APP 403407 (Entrez Gene)
Chr31 Q28280 (UniProt | EBI)
NM_001006601 (RefSeq)
chicken APP 374198 (Entrez Gene)
Chr1 NP_989639 (RefSeq)
NM_204308 (RefSeq)
zebrafish appb 170846 (Entrez Gene)
Chr9 NP_690842 (RefSeq)
NM_152886 (RefSeq)
frog, western clawed app 448208 (Entrez Gene)
Chr2 NP_001005698 (RefSeq)
NM_001005698 (RefSeq)
macaque, rhesus APP 100427716 (Entrez Gene)
Chr3 P29216 (UniProt | EBI)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory