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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human SMAD3 HGNC:6769 (HGNC)
4088 (Entrez Gene)
603109 (OMIM)
HGNC homology
Chr15 q22.33 Chr15:67065698-67195195 (+)
Loeys-Dietz syndrome 3
P84022 (UniProt | EBI)
NM_001145104 (RefSeq)
mouse Smad3 MGI:1201674 (MGI)
17127 (Entrez Gene)
Gene Tree
HGNC homology
Chr9 34.22 cM Chr9:63646767-63757994 (-)
ENSMUSG00000032402 (Ensembl Gene Model)
ENSMUSP00000034973 (Ensembl)
ENSMUST00000034973 (Ensembl)
rat Smad3 25631 (Entrez Gene)
Chr8 q24 P84025 (UniProt | EBI)
NM_013095 (RefSeq)
chimpanzee SMAD3 748161 (Entrez Gene)
Chr15 XP_003314773 (RefSeq)
cattle SMAD3 515125 (Entrez Gene)
Chr10 NP_001192734 (RefSeq)
NM_001205805 (RefSeq)
dog SMAD3 610902 (Entrez Gene)
Chr30 NP_001164300 (RefSeq)
NM_001170829 (RefSeq)
chicken SMAD3 395132 (Entrez Gene)
Chr10 P84023 (UniProt | EBI)
NM_204475 (RefSeq)
zebrafish smad3b 326283 (Entrez Gene)
Chr18 NP_778258 (RefSeq)
NM_175083 (RefSeq)
frog, western clawed smad3 493272 (Entrez Gene)
Chr3 NP_001008436 (RefSeq)
NM_001008436 (RefSeq)
macaque, rhesus SMAD3 711355 (Entrez Gene)
Chr7 NP_001253089 (RefSeq)
NM_001266160 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory