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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human COL2A1 HGNC:2200 (HGNC)
1280 (Entrez Gene)
120140 (OMIM)
HGNC homology
Chr12 q13.11 Chr12:47972965-48025286 (-)
Achondrogenesis, Type II; ACG2
Avascular Necrosis of Femoral Head, Primary; ANFH
Collagen, Type II, Alpha-1; COL2A1
Czech Dysplasia
Epiphyseal Dysplasia, Multiple, with Myopia and Conductive Deafness;
Kniest Dysplasia
Legg-Calve-Perthes Disease; LCPD
Osteoarthritis with Mild Chondrodysplasia; OSCDP
Otospondylomegaepiphyseal Dysplasia; OSMED
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type; PLSDT
Spondyloepimetaphyseal Dysplasia, Strudwick Type; SEMDSTWK
Spondyloepiphyseal Dysplasia Congenita; SEDC
Spondyloepiphyseal Dysplasia, Stanescu Type; SEDSTN
Spondyloperipheral Dysplasia
Stickler Syndrome, Type I, Nonsyndromic Ocular
Stickler Syndrome, Type I; STL1
P02458 (UniProt | EBI)
NM_001844 (RefSeq)
mouse Col2a1 MGI:88452 (MGI)
12824 (Entrez Gene)
Gene Tree
HGNC homology
Chr15 53.97 cM Chr15:97975602-98004695 (-)
Achondrogenesis, Type II; ACG2
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type; PLSDT
Spondyloepiphyseal Dysplasia Congenita; SEDC
Stickler Syndrome, Type I, Nonsyndromic Ocular
OTTMUSG00000021708 (VEGA)
OTTMUSP00000024255 (VEGA)
OTTMUST00000051504 (VEGA)
rat Col2a1 25412 (Entrez Gene)
Chr7 q36 P05539 (UniProt | EBI)
NM_012929 (RefSeq)
chimpanzee COL2A1 451860 (Entrez Gene)
Chr12 XP_009423791 (RefSeq)
rhesus macaque COL2A1 704851 (Entrez Gene)
Chr11 XP_001100739 (RefSeq)
cattle COL2A1 407142 (Entrez Gene)
Chr5 P02459 (UniProt | EBI)
NM_001001135 (RefSeq)
dog COL2A1 403826 (Entrez Gene)
Chr27 NP_001006952 (RefSeq)
NM_001006951 (RefSeq)
chicken COL2A1 395069 (Entrez Gene)
ChrUN P02460 (UniProt | EBI)
NM_204426 (RefSeq)
western clawed frog col2a1 394828 (Entrez Gene)
ChrUN Q6P4Z2 (UniProt | EBI)
NM_203889 (RefSeq)
zebrafish col2a1a 562496 (Entrez Gene)
Chr8 NP_571367 (RefSeq)
NM_131292 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory