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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human GNAS HGNC:4392 (HGNC)
2778 (Entrez Gene)
139320 (OMIM)
HGNC homology
Chr20 q13.3 Chr20:58839740-58911195 (+)
Acth-Independent Macronodular Adrenal Hyperplasia; AIMAH1
McCune-Albright Syndrome; MAS
Osseous Heteroplasia, Progressive; POH
Pituitary Adenoma, Growth Hormone-Secreting, 1; PAGH1
Pseudohypoparathyroidism, Type IA; PHP1A
Pseudohypoparathyroidism, Type IB; PHP1B
Pseudohypoparathyroidism, Type Ic; PHP1C
Pseudopseudohypoparathyroidism; PPHP
O95467 (UniProt | EBI)
NM_001077488 (RefSeq)
mouse Gnas MGI:95777 (MGI)
14683 (Entrez Gene)
Gene Tree
HGNC homology
Chr2 97.89 cM Chr2:174284320-174346744 (+)
Pseudohypoparathyroidism, Type IA; PHP1A
Pseudopseudohypoparathyroidism; PPHP
Schizophrenia; SCZD
OTTMUSG00000016388 (VEGA)
OTTMUSP00000017632 (VEGA)
OTTMUST00000039462 (VEGA)
rat Gnas 24896 (Entrez Gene)
Chr3 q42 Q63803 (UniProt | EBI)
NM_021845 (RefSeq)
chimpanzee LOC469986 469986 (Entrez Gene)
Chr20 XP_009435771 (RefSeq)
rhesus macaque LOC694289 694289 (Entrez Gene)
Chr10 XP_015004194 (RefSeq)
cattle GNAS 281793 (Entrez Gene)
Chr13 q22 O18979 (UniProt | EBI)
NM_181021 (RefSeq)
dog GNAS 403943 (Entrez Gene)
Chr24 P63091 (UniProt | EBI)
NM_001003263 (RefSeq)
chicken GNAS 419313 (Entrez Gene)
Chr20 XP_015152033 (RefSeq)
western clawed frog gnas 407931 (Entrez Gene)
ChrUN XP_012810204 (RefSeq)
NM_213690 (RefSeq)
zebrafish gnas 557353 (Entrez Gene)
Chr6 XP_001335732 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory