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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human LDLR HGNC:6547 (HGNC)
3949 (Entrez Gene)
606945 (OMIM)
LDL receptor (MyGene.info)
HGNC homology
Chr19 p13.2 Chr19:11089362-11133830 (+)
familial hypercholesterolemia
P01130 (UniProt | EBI)
NM_001195799 (RefSeq)
mouse Ldlr MGI:96765 (MGI)
16835 (Entrez Gene)
Gene Tree
HGNC homology
Chr9 7.87 cM Chr9:21723576-21749919 (+)
familial hypercholesterolemia
fatty liver disease
16835 (NCBI Gene Model)
P35951 (UniProt | EBI)
NM_010700 (RefSeq)
rat Ldlr 300438 (Entrez Gene)
Chr8 q13 P35952 (UniProt | EBI)
NM_175762 (RefSeq)
chimpanzee LDLR 455722 (Entrez Gene)
Chr19 XP_024206933 (RefSeq)
cattle LDLR 281276 (Entrez Gene)
Chr7 P01131 (UniProt | EBI)
NM_001166530 (RefSeq)
dog LDLR 100683160 (Entrez Gene)
Chr20 XP_022262751 (RefSeq)
zebrafish ldlra 387529 (Entrez Gene)
Chr3 NP_001025454 (RefSeq)
NM_001030283 (RefSeq)
frog, western clawed ldlr 100495826 (Entrez Gene)
Chr3 XP_002942891 (RefSeq)
macaque, rhesus LDLR 574283 (Entrez Gene)
Chr19 NP_001028078 (RefSeq)
NM_001032906 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory