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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human PITX2 HGNC:9005 (HGNC)
5308 (Entrez Gene)
601542 (OMIM)
PITX2 (MyGene.info)
HGNC homology
Chr4 q25 Chr4:110617423-110642123 (-)
Axenfeld-Rieger syndrome type 1
iridogoniodysgenesis syndrome
Peters anomaly
Q99697 (UniProt | EBI)
NM_000325 (RefSeq)
mouse Pitx2 MGI:109340 (MGI)
18741 (Entrez Gene)
Gene Tree
HGNC homology
Chr3 57.84 cM Chr3:129199878-129219591 (+)
Axenfeld-Rieger syndrome type 1
OTTMUSG00000037721 (VEGA)
OTTMUSP00000054645 (VEGA)
OTTMUST00000097424 (VEGA)
rat Pitx2 54284 (Entrez Gene)
Chr2 q42 Q9R0W1 (UniProt | EBI)
NM_019334 (RefSeq)
chimpanzee PITX2 461438 (Entrez Gene)
Chr4 XP_001141234 (RefSeq)
cattle PITX2 506721 (Entrez Gene)
Chr6 NP_001091460 (RefSeq)
NM_001097991 (RefSeq)
dog PITX2 487902 (Entrez Gene)
Chr32 XP_851370 (RefSeq)
chicken PITX2 395862 (Entrez Gene)
Chr4 O93385 (UniProt | EBI)
NM_205010 (RefSeq)
zebrafish pitx2 30164 (Entrez Gene)
Chr14 Q9W5Z2 (UniProt | EBI)
NM_130975 (RefSeq)
frog, western clawed pitx2 549981 (Entrez Gene)
Chr1 NP_001017227 (RefSeq)
NM_001017227 (RefSeq)
macaque, rhesus PITX2 699737 (Entrez Gene)
Chr5 XP_001091288 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory