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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human CDK4 HGNC:1773 (HGNC)
1019 (Entrez Gene)
123829 (OMIM)
Cyclin-dependent kinase 4 (MyGene.info)
HGNC homology
Chr12 q14.1 Chr12:57747727-57752447 (-)
skin melanoma
P11802 (UniProt | EBI)
NM_052984 (RefSeq)
mouse Cdk4 MGI:88357 (MGI)
12567 (Entrez Gene)
Gene Tree
HGNC homology
Chr10 74.5 cM Chr10:127063535-127067288 (+)
type 1 diabetes mellitus
12567 (NCBI Gene Model)
P30285 (UniProt | EBI)
NM_009870 (RefSeq)
rat Cdk4 94201 (Entrez Gene)
Chr7 q22 P35426 (UniProt | EBI)
NM_053593 (RefSeq)
chimpanzee CDK4 452025 (Entrez Gene)
Chr12 XP_509173 (RefSeq)
cattle CDK4 510618 (Entrez Gene)
Chr5 Q32KY4 (UniProt | EBI)
NM_001037594 (RefSeq)
dog CDK4 481131 (Entrez Gene)
Chr10 XP_022279812 (RefSeq)
zebrafish cdk4 777730 (Entrez Gene)
Chr11 NP_001071245 (RefSeq)
NM_001077777 (RefSeq)
frog, western clawed cdk4 549496 (Entrez Gene)
ChrUN NP_001016742 (RefSeq)
NM_001016742 (RefSeq)
macaque, rhesus CDK4 715650 (Entrez Gene)
Chr11 NP_001248276 (RefSeq)
NM_001261347 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory