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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human MME HGNC:7154 (HGNC)
4311 (Entrez Gene)
120520 (OMIM)
Neprilysin (MyGene.info)
HGNC homology
Chr3 q25.2 Chr3:155024124-155183729 (+)
Charcot-Marie-Tooth disease axonal type 2T
P08473 (UniProt | EBI)
NM_001354642 (RefSeq)
mouse Mme MGI:97004 (MGI)
17380 (Entrez Gene)
Gene Tree
HGNC homology
Chr3 29.97 cM Chr3:63241537-63386030 (+)
Alzheimer's disease
OTTMUSG00000051889 (VEGA)
OTTMUSP00000069989 (VEGA)
OTTMUST00000130651 (VEGA)
rat Mme 24590 (Entrez Gene)
Chr2 q31 P07861 (UniProt | EBI)
NM_012608 (RefSeq)
chimpanzee MME 460792 (Entrez Gene)
Chr3 XP_001148665 (RefSeq)
cattle MME 536741 (Entrez Gene)
Chr1 NP_001179813 (RefSeq)
NM_001192884 (RefSeq)
dog MME 477120 (Entrez Gene)
Chr23 NP_001275995 (RefSeq)
NM_001289066 (RefSeq)
chicken MME 425031 (Entrez Gene)
Chr9 NP_001004412 (RefSeq)
NM_001004412 (RefSeq)
macaque, rhesus MME 707667 (Entrez Gene)
Chr2 NP_001247743 (RefSeq)
NM_001260814 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory