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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human TNF HGNC:11892 (HGNC)
7124 (Entrez Gene)
191160 (OMIM)
Tumor necrosis factor-alpha (MyGene.info)
HGNC homology
Chr6 p21.33 Chr6:31575567-31578336 (+)
P01375 (UniProt | EBI)
NM_000594 (RefSeq)
mouse Tnf MGI:104798 (MGI)
21926 (Entrez Gene)
Gene Tree
HGNC homology
Chr17 18.59 cM Chr17:35199381-35202007 (-)
congestive heart failure
dilated cardiomyopathy
idiopathic pulmonary fibrosis
inflammatory bowel disease
multiple sclerosis
rheumatoid arthritis
OTTMUSG00000037196 (VEGA)
OTTMUSP00000053529 (VEGA)
OTTMUST00000095888 (VEGA)
rat Tnf 24835 (Entrez Gene)
Chr20 p12 P16599 (UniProt | EBI)
NM_012675 (RefSeq)
chimpanzee TNF 494186 (Entrez Gene)
Chr6 Q8HZD9 (UniProt | EBI)
NM_001045511 (RefSeq)
cattle TNF 280943 (Entrez Gene)
Chr23 q22 Q06599 (UniProt | EBI)
NM_173966 (RefSeq)
dog TNF 403922 (Entrez Gene)
Chr12 P51742 (UniProt | EBI)
NM_001003244 (RefSeq)
frog, western clawed tnf 100134991 (Entrez Gene)
Chr8 NP_001107143 (RefSeq)
NM_001113671 (RefSeq)
macaque, rhesus TNF 715467 (Entrez Gene)
Chr4 P48094 (UniProt | EBI)
NM_001047149 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory