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Vertebrate Homology Class
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
460

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human TP53 HGNC:11998 (HGNC)
7157 (Entrez Gene)
191170 (OMIM)
Chr17 p13.1 Chr17:7668402-7687550 (-)
GRCh38
Adrenocortical Carcinoma, Hereditary; ADCC
Basal Cell Carcinoma, Susceptibility to, 7; BCC7
Breast Cancer
Colorectal Cancer; CRC
Glioma Susceptibility 1; GLM1
Hepatocellular Carcinoma
Li-Fraumeni Syndrome 1; LFS1
Nasopharyngeal Carcinoma
Osteogenic Sarcoma
Pancreatic Cancer
Papilloma of Choroid Plexus; CPP
P04637 (UniProt | EBI)
NM_000546 (RefSeq)
mouse Trp53 MGI:98834 (MGI)
22059 (Entrez Gene)
Gene Tree
VISTA-Point
Chr11 42.83 cM Chr11:69580359-69591873 (+)
GRCm38
Bladder Cancer
Breast Cancer
Breast-Ovarian Cancer, Familial, Susceptibility to, 1; BROVCA1
Dyskeratosis Congenita, Autosomal Dominant, 1; DKCA1
Endometrial Cancer
Li-Fraumeni Syndrome 1; LFS1
Lung Cancer
Medulloblastoma; MDB
Mesothelioma, Malignant; MESOM
Osteogenic Sarcoma
Ovarian Cancer
Pancreatic Cancer
Prostate Cancer
Rhabdomyosarcoma 2; RMS2
Small Cell Cancer of the Lung
Squamous Cell Carcinoma, Head and Neck; HNSCC
OTTMUSG00000005982 (VEGA)
OTTMUSP00000006194 (VEGA)
OTTMUST00000013379 (VEGA)
rat Tp53 24842 (Entrez Gene)
Chr10 q24 P10361 (UniProt | EBI)
NM_030989 (RefSeq)
chimpanzee TP53 455214 (Entrez Gene)
Chr17 XP_001172077 (RefSeq)
rhesus macaque TP53 716170 (Entrez Gene)
Chr16 P56424 (UniProt | EBI)
NM_001047151 (RefSeq)
dog TP53 403869 (Entrez Gene)
Chr5 Q29537 (UniProt | EBI)
NM_001003210 (RefSeq)
zebrafish tp53 30590 (Entrez Gene)
Chr5 P79734 (UniProt | EBI)
NM_001271820 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory