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Vertebrate Homology Class
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
4349

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human MTHFR HGNC:7436 (HGNC)
4524 (Entrez Gene)
607093 (OMIM)
Chr1 p36.3 Chr1:11785730-11806103 (-)
GRCh38
Homocystinuria Due to Deficiency of N(5,10)-Methylenetetrahydrofolate Reductase Activity
Neural Tube Defects, Folate-Sensitive
Schizophrenia; SCZD
Thrombophilia Due to Thrombin Defect; THPH1
P42898 (UniProt | EBI)
NM_005957 (RefSeq)
mouse Mthfr MGI:106639 (MGI)
17769 (Entrez Gene)
Gene Tree
VISTA-Point
Chr4 78.67 cM Chr4:148039077-148059551 (+)
GRCm38
Homocysteinemia
Neural Tube Defects, Folate-Sensitive
OTTMUSG00000010193 (VEGA)
OTTMUSP00000010828 (VEGA)
OTTMUST00000023686 (VEGA)
rat Mthfr 362657 (Entrez Gene)
Chr5 q36 XP_001074061 (RefSeq)
chimpanzee MTHFR 469800 (Entrez Gene)
Chr1 XP_001141040 (RefSeq)
rhesus macaque LOC714840 714840 (Entrez Gene)
Chr1 XP_001105017 (RefSeq)
cattle MTHFR 497032 (Entrez Gene)
Chr16 Q5I598 (UniProt | EBI)
NM_001011685 (RefSeq)
dog MTHFR 478230 (Entrez Gene)
Chr2 XP_535405 (RefSeq)
chicken MTHFR 419489 (Entrez Gene)
Chr21 XP_417645 (RefSeq)
western clawed frog mthfr 100125082 (Entrez Gene)
ChrUN NP_001096464 (RefSeq)
NM_001102994 (RefSeq)
zebrafish mthfr 567547 (Entrez Gene)
Chr8 NP_001121727 (RefSeq)
NM_001128255 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory