About   Help   FAQ
HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
select all deselect all Go
human MTHFR HGNC:7436 (HGNC)
4524 (Entrez Gene)
607093 (OMIM)
HGNC homology
Chr1 p36.22 Chr1:11785730-11806103 (-)
neural tube defect
P42898 (UniProt | EBI)
NM_005957 (RefSeq)
mouse Mthfr MGI:106639 (MGI)
17769 (Entrez Gene)
Gene Tree
HGNC homology
Chr4 78.67 cM Chr4:148039077-148059551 (+)
neural tube defect
OTTMUSG00000010193 (VEGA)
OTTMUSP00000010828 (VEGA)
OTTMUST00000023686 (VEGA)
rat Mthfr 362657 (Entrez Gene)
Chr5 q36 XP_006225678 (RefSeq)
chimpanzee MTHFR 469800 (Entrez Gene)
Chr1 XP_009446635 (RefSeq)
cattle MTHFR 497032 (Entrez Gene)
Chr16 Q5I598 (UniProt | EBI)
NM_001011685 (RefSeq)
dog MTHFR 478230 (Entrez Gene)
Chr2 XP_005618050 (RefSeq)
chicken MTHFR 419489 (Entrez Gene)
Chr21 NP_001315420 (RefSeq)
NM_001328491 (RefSeq)
zebrafish mthfr 567547 (Entrez Gene)
Chr8 NP_001121727 (RefSeq)
NM_001128255 (RefSeq)
frog, western clawed mthfr 100125082 (Entrez Gene)
Chr7 NP_001096464 (RefSeq)
NM_001102994 (RefSeq)
macaque, rhesus MTHFR 714840 (Entrez Gene)
Chr1 XP_014967739 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory