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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human LMNA HGNC:6636 (HGNC)
4000 (Entrez Gene)
150330 (OMIM)
HGNC homology
Chr1 q22 Chr1:156082546-156140089 (+)
Cardiomyopathy, Dilated, 1A; CMD1A
Cardiomyopathy, Dilated, with Hypergonadotropic Hypogonadism
Charcot-Marie-Tooth Disease, Axonal, Type 2B1; CMT2B1
Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant; EDMD2
Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive; EDMD3
Heart-Hand Syndrome, Slovenian Type
Hutchinson-Gilford Progeria Syndrome; HGPS
Lipodystrophy, Familial Partial, Type 2; FPLD2
Mandibuloacral Dysplasia with Type A Lipodystrophy; MADA
Muscular Dystrophy, Congenital, Lmna-Related
Muscular Dystrophy, Limb-Girdle, Type 1B; LGMD1B
Restrictive Dermopathy, Lethal
P02545 (UniProt | EBI)
NM_001282626 (RefSeq)
mouse Lmna MGI:96794 (MGI)
16905 (Entrez Gene)
Gene Tree
HGNC homology
Chr3 38.84 cM Chr3:88480147-88509956 (-)
Achalasia, Familial Esophageal
Cardiomyopathy, Dilated, 1A; CMD1A
Charcot-Marie-Tooth Disease, Axonal, Type 2B1; CMT2B1
Emery-Dreifuss Muscular Dystrophy 2, Autosomal Dominant; EDMD2
Hutchinson-Gilford Progeria Syndrome; HGPS
Muscular Dystrophy, Congenital, Lmna-Related
OTTMUSG00000030317 (VEGA)
OTTMUSP00000039297 (VEGA)
OTTMUST00000075092 (VEGA)
rat Lmna 60374 (Entrez Gene)
Chr2 q34 P48679 (UniProt | EBI)
NM_001002016 (RefSeq)
chimpanzee LMNA 457385 (Entrez Gene)
Chr1 NP_001092024 (RefSeq)
NM_001098554 (RefSeq)
cattle LMNA 404144 (Entrez Gene)
Chr3 NP_001029225 (RefSeq)
NM_001034053 (RefSeq)
dog LMNA 480124 (Entrez Gene)
Chr7 NP_001274080 (RefSeq)
NM_001287151 (RefSeq)
zebrafish lmna 195815 (Entrez Gene)
Chr16 NP_694503 (RefSeq)
NM_152971 (RefSeq)
frog, western clawed lmna 733973 (Entrez Gene)
ChrUN NP_001039148 (RefSeq)
NM_001045683 (RefSeq)
macaque, rhesus LMNA 719414 (Entrez Gene)
Chr1 NP_001244822 (RefSeq)
NM_001257893 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory