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Vertebrate Homology Class
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human IRS1 HGNC:6125 (HGNC)
3667 (Entrez Gene)
147545 (OMIM)
Chr2 q36 Chr2:226731317-226799829 (-)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM
Insulin Receptor Substrate 1; IRS1
P35568 (UniProt | EBI)
NM_005544 (RefSeq)
mouse Irs1 MGI:99454 (MGI)
16367 (Entrez Gene)
Gene Tree
Chr1 42.0 cM Chr1:82233101-82291416 (-)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM
OTTMUSG00000016464 (VEGA)
OTTMUSP00000017705 (VEGA)
OTTMUST00000039671 (VEGA)
rat Irs1 25467 (Entrez Gene)
Chr9 q34 P35570 (UniProt | EBI)
NM_012969 (RefSeq)
chimpanzee IRS1 459985 (Entrez Gene)
Chr2B XP_003309544 (RefSeq)
cattle IRS1 538598 (Entrez Gene)
Chr2 XP_003581919 (RefSeq)
dog IRS1 486148 (Entrez Gene)
Chr25 XP_543274 (RefSeq)
chicken IRS1 101749888 (Entrez Gene)
Chr9 XP_004951158 (RefSeq)
western clawed frog LOC100495320 100495320 (Entrez Gene)
ChrUN XP_002937134 (RefSeq)
zebrafish irs1 559281 (Entrez Gene)
Chr15 XP_687702 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory