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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human IRS1 HGNC:6125 (HGNC)
3667 (Entrez Gene)
147545 (OMIM)
IRS1 (MyGene.info)
HGNC homology
Chr2 q36.3 Chr2:226731317-226798790 (-)
type 2 diabetes mellitus
P35568 (UniProt | EBI)
NM_005544 (RefSeq)
mouse Irs1 MGI:99454 (MGI)
16367 (Entrez Gene)
Gene Tree
HGNC homology
Chr1 42.0 cM Chr1:82233101-82291416 (-)
type 2 diabetes mellitus
OTTMUSG00000016464 (VEGA)
OTTMUSP00000017705 (VEGA)
OTTMUST00000039671 (VEGA)
rat Irs1 25467 (Entrez Gene)
Chr9 q34 P35570 (UniProt | EBI)
NM_012969 (RefSeq)
chimpanzee IRS1 459985 (Entrez Gene)
Chr2B XP_003309544 (RefSeq)
cattle IRS1 538598 (Entrez Gene)
Chr2 XP_003585821 (RefSeq)
dog IRS1 486148 (Entrez Gene)
Chr25 XP_543274 (RefSeq)
chicken IRS1 101749888 (Entrez Gene)
Chr9 NM_001031570 (RefSeq)
zebrafish irs1 559281 (Entrez Gene)
Chr15 XP_687702 (RefSeq)
frog, western clawed irs1 100495320 (Entrez Gene)
Chr5 XP_012818903 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory