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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human PSEN2 HGNC:9509 (HGNC)
5664 (Entrez Gene)
600759 (OMIM)
PSEN2 (MyGene.info)
HGNC homology
Chr1 q42.13 Chr1:226870572-226903829 (+)
Alzheimer's disease 4
dilated cardiomyopathy 1V
P49810 (UniProt | EBI)
NM_012486 (RefSeq)
mouse Psen2 MGI:109284 (MGI)
19165 (Entrez Gene)
Gene Tree
HGNC homology
Chr1 84.19 cM Chr1:180227004-180263438 (-)
OTTMUSG00000021488 (VEGA)
OTTMUSP00000023891 (VEGA)
OTTMUST00000050924 (VEGA)
rat Psen2 81751 (Entrez Gene)
Chr13 q26 O88777 (UniProt | EBI)
NM_031087 (RefSeq)
chimpanzee PSEN2 457790 (Entrez Gene)
Chr1 XP_001142009 (RefSeq)
cattle PSEN2 282010 (Entrez Gene)
Chr16 q16 Q9XT96 (UniProt | EBI)
NM_174440 (RefSeq)
dog PSEN2 490382 (Entrez Gene)
Chr7 NP_001271394 (RefSeq)
NM_001284465 (RefSeq)
chicken PSEN2 374188 (Entrez Gene)
Chr3 Q90X07 (UniProt | EBI)
NM_204302 (RefSeq)
zebrafish psen2 58026 (Entrez Gene)
Chr1 Q90ZE4 (UniProt | EBI)
NM_131514 (RefSeq)
frog, western clawed psen2 549935 (Entrez Gene)
Chr5 NP_001017181 (RefSeq)
NM_001017181 (RefSeq)
macaque, rhesus PSEN2 698770 (Entrez Gene)
Chr1 NP_001248546 (RefSeq)
NM_001261617 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory