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Vertebrate Homology Class
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human PLEC HGNC:9069 (HGNC)
5339 (Entrez Gene)
601282 (OMIM)
Chr8 q24 Chr8:143915147-143976745 (-)
Epidermolysis Bullosa Junctionalis with Pyloric Atresia
Epidermolysis Bullosa Simplex, Ogna Type
Epidermolysis Bullosa Simplex with Muscular Dystrophy
Epidermolysis Bullosa Simplex with Pyloric Atresia
Muscular Dystrophy, Limb-Girdle, Type 2q; LGMD2Q
Q15149 (UniProt | EBI)
NM_000445 (RefSeq)
mouse Plec MGI:1277961 (MGI)
18810 (Entrez Gene)
Gene Tree
Chr15 35.48 cM Chr15:76170975-76232574 (-)
Epidermolysis Bullosa Simplex, Ogna Type
Epidermolysis Bullosa Simplex with Muscular Dystrophy
OTTMUSG00000035240 (VEGA)
OTTMUSP00000049128 (VEGA)
OTTMUST00000089827 (VEGA)
rat Plec 64204 (Entrez Gene)
Chr7 q34 P30427 (UniProt | EBI)
NM_022401 (RefSeq)
chimpanzee PLEC 464454 (Entrez Gene)
Chr8 XP_009454416 (RefSeq)
rhesus macaque PLEC 699517 (Entrez Gene)
Chr8 XP_001088212 (RefSeq)
cattle LOC786966 786966 (Entrez Gene)
Chr14 XP_003586919 (RefSeq)
dog PLEC 482083 (Entrez Gene)
Chr13 XP_539204 (RefSeq)
western clawed frog plec 100145182 (Entrez Gene)
ChrUN XP_002943468 (RefSeq)
zebrafish pleca 567639 (Entrez Gene)
Chr19 NP_001093502 (RefSeq)
NM_001100032 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory