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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human CHEK2 HGNC:16627 (HGNC)
11200 (Entrez Gene)
604373 (OMIM)
CHEK2 (MyGene.info)
HGNC homology
Chr22 q12.1 Chr22:28687743-28741866 (-)
breast cancer
Li-Fraumeni syndrome
prostate cancer
O96017 (UniProt | EBI)
NM_001005735 (RefSeq)
mouse Chek2 MGI:1355321 (MGI)
50883 (Entrez Gene)
Gene Tree
HGNC homology
Chr5 53.73 cM Chr5:110839979-110874145 (+)
OTTMUSG00000054224 (VEGA)
OTTMUSP00000071369 (VEGA)
OTTMUST00000134619 (VEGA)
rat Chek2 114212 (Entrez Gene)
Chr12 q16 NP_446129 (RefSeq)
NM_053677 (RefSeq)
chimpanzee CHEK2 458733 (Entrez Gene)
Chr22 XP_016794378 (RefSeq)
cattle CHEK2 518897 (Entrez Gene)
Chr17 NP_001029703 (RefSeq)
NM_001034531 (RefSeq)
dog CHEK2 486338 (Entrez Gene)
Chr26 XP_005636450 (RefSeq)
chicken CHEK2 768913 (Entrez Gene)
Chr15 NP_001073576 (RefSeq)
NM_001080107 (RefSeq)
zebrafish chek2 336998 (Entrez Gene)
Chr5 NP_956339 (RefSeq)
NM_200045 (RefSeq)
frog, western clawed chek2 100144952 (Entrez Gene)
Chr1 NP_001119996 (RefSeq)
NM_001126524 (RefSeq)
macaque, rhesus CHEK2 713668 (Entrez Gene)
Chr10 XP_015005467 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory