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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human SPR HGNC:11257 (HGNC)
6697 (Entrez Gene)
182125 (OMIM)
HGNC homology
Chr2 p14-p12 Chr2:72887383-72892160 (+)
Dystonia, Dopa-Responsive, Due to Sepiapterin Reductase Deficiency
P35270 (UniProt | EBI)
NM_003124 (RefSeq)
mouse Spr MGI:103078 (MGI)
20751 (Entrez Gene)
Gene Tree
Chr6 37.15 cM Chr6:85130176-85137766 (-)
Dystonia, Dopa-Responsive, Due to Sepiapterin Reductase Deficiency
Parkinson Disease 3, Autosomal Dominant; PARK3
OTTMUSG00000037795 (VEGA)
OTTMUSP00000054720 (VEGA)
OTTMUST00000097538 (VEGA)
rat Spr 29270 (Entrez Gene)
Chr4 q34 P18297 (UniProt | EBI)
NM_019181 (RefSeq)
chimpanzee SPR 470403 (Entrez Gene)
Chr2A XP_525784 (RefSeq)
rhesus macaque SPR 705317 (Entrez Gene)
Chr13 NP_001247478 (RefSeq)
NM_001260549 (RefSeq)
cattle SPR 533836 (Entrez Gene)
Chr11 Q17QK8 (UniProt | EBI)
NM_001076003 (RefSeq)
dog SPR 483118 (Entrez Gene)
Chr17 XP_540234 (RefSeq)
chicken SPR 425255 (Entrez Gene)
Chr4 XP_423038 (RefSeq)
western clawed frog spr 100145068 (Entrez Gene)
ChrUN B0BML7 (UniProt | EBI)
NM_001126595 (RefSeq)
zebrafish spra 554136 (Entrez Gene)
Chr5 NP_001019601 (RefSeq)
NM_001024430 (RefSeq)
sprb 795445 (Entrez Gene)
Chr8 NP_001122262 (RefSeq)
NM_001128790 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory