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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human PRF1 HGNC:9360 (HGNC)
5551 (Entrez Gene)
170280 (OMIM)
Perforin (MyGene.info)
HGNC homology
Chr10 q22.1 Chr10:70597348-70602775 (-)
aplastic anemia
familial hemophagocytic lymphohistiocytosis 2
non-Hodgkin lymphoma
P14222 (UniProt | EBI)
NM_005041 (RefSeq)
mouse Prf1 MGI:97551 (MGI)
18646 (Entrez Gene)
Gene Tree
HGNC homology
Chr10 32.18 cM Chr10:61297546-61304263 (+)
familial hemophagocytic lymphohistiocytosis 2
multiple sclerosis
type 1 diabetes mellitus
18646 (NCBI Gene Model)
P10820 (UniProt | EBI)
NM_011073 (RefSeq)
rat Prf1 50669 (Entrez Gene)
Chr20 q11 P35763 (UniProt | EBI)
NM_017330 (RefSeq)
chimpanzee PRF1 450512 (Entrez Gene)
Chr10 XP_001171235 (RefSeq)
cattle PRF1 369025 (Entrez Gene)
Chr28 NP_001137207 (RefSeq)
NM_001143735 (RefSeq)
dog PRF1 489030 (Entrez Gene)
Chr4 NP_001184111 (RefSeq)
NM_001197182 (RefSeq)
chicken PRF1 101750363 (Entrez Gene)
Chr17 XP_015135083 (RefSeq)
zebrafish prf1.1 100000903 (Entrez Gene)
Chr3 NP_001304691 (RefSeq)
NM_001317762 (RefSeq)
prf1.7 100535230 (Entrez Gene)
Chr19 XP_003200648 (RefSeq)
prf1.9 569443 (Entrez Gene)
Chr3 NP_001304687 (RefSeq)
NM_001317758 (RefSeq)
frog, western clawed LOC100489175 100489175 (Entrez Gene)
ChrUN XP_002942088 (RefSeq)
LOC100489324 100489324 (Entrez Gene)
ChrUN XP_017945407 (RefSeq)
LOC100489487 100489487 (Entrez Gene)
ChrUN XP_012809553 (RefSeq)
LOC100492973 100492973 (Entrez Gene)
Chr9 XP_012826230 (RefSeq)
LOC100493140 100493140 (Entrez Gene)
Chr9 XP_012826229 (RefSeq)
LOC100493300 100493300 (Entrez Gene)
ChrUN XP_002941529 (RefSeq)
LOC101732506 101732506 (Entrez Gene)
ChrUN XP_004918449 (RefSeq)
LOC101732838 101732838 (Entrez Gene)
prf1 100491518 (Entrez Gene)
ChrUN XP_017945408 (RefSeq)
macaque, rhesus PRF1 710241 (Entrez Gene)
Chr9 XP_001107967 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory