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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human MECP2 HGNC:6990 (HGNC)
4204 (Entrez Gene)
300005 (OMIM)
HGNC homology
ChrX q28 ChrX:154021800-154097731 (-)
Autism, Susceptibility to, X-Linked 3; AUTSX3
Encephalopathy, Neonatal Severe, Due to Mecp2 Mutations
Lubs X-Linked Mental Retardation Syndrome; MRXSL
Mental Retardation, X-Linked, Syndromic 13; MRXS13
Rett Syndrome; RTT
P51608 (UniProt | EBI)
NM_001110792 (RefSeq)
mouse Mecp2 MGI:99918 (MGI)
17257 (Entrez Gene)
Gene Tree
HGNC homology
ChrX 37.63 cM ChrX:74026592-74085690 (-)
Rett Syndrome; RTT
OTTMUSG00000017654 (VEGA)
OTTMUSP00000019680 (VEGA)
OTTMUST00000043832 (VEGA)
rat Mecp2 29386 (Entrez Gene)
ChrX Q00566 (UniProt | EBI)
NM_022673 (RefSeq)
chimpanzee MECP2 465936 (Entrez Gene)
ChrX XP_521333 (RefSeq)
cattle MECP2 539629 (Entrez Gene)
ChrX NP_001193481 (RefSeq)
NM_001206552 (RefSeq)
dog MECP2 612973 (Entrez Gene)
ChrX XP_013967036 (RefSeq)
zebrafish mecp2 335250 (Entrez Gene)
Chr8 NP_001315484 (RefSeq)
NM_001328555 (RefSeq)
frog, western clawed mecp2 100216110 (Entrez Gene)
Chr8 NP_001135563 (RefSeq)
NM_001142091 (RefSeq)
macaque, rhesus MECP2 700174 (Entrez Gene)
ChrX NP_001244471 (RefSeq)
NM_001257542 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory