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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human C4A HGNC:1323 (HGNC)
720 (Entrez Gene)
120810 (OMIM)
C4A (MyGene.info)
HGNC homology
Chr6 p21.33 Chr6:31982057-32002680 (+)
complement component 4a deficiency
P0C0L4 (UniProt | EBI)
NM_001252204 (RefSeq)
C4B HGNC:1324 (HGNC)
721 (Entrez Gene)
120820 (OMIM)
Complement component 4B (MyGene.info)
HGNC homology
Chr6 p21.33 Chr6:32014795-32035418 (+)
complement component 4b deficiency
P0C0L5 (UniProt | EBI)
NM_001002029 (RefSeq)
mouse C4a MGI:98320 (MGI)
625018 (Entrez Gene)
Gene Tree
HGNC homology
Chr17 18.37 cM Chr17:34809092-34823460 (-)
625018 (NCBI Gene Model)
NP_035543 (RefSeq)
NM_011413 (RefSeq)
C4b MGI:88228 (MGI)
12268 (Entrez Gene)
Gene Tree
HGNC homology
Chr17 18.29 cM Chr17:34728380-34743882 (-)
systemic lupus erythematosus
ENSMUSG00000073418 (Ensembl Gene Model)
ENSMUSP00000069418 (Ensembl)
ENSMUST00000069507 (Ensembl)
rat C4a 24233 (Entrez Gene)
Chr20 p12 P08649 (UniProt | EBI)
NM_031504 (RefSeq)
C4b 406161 (Entrez Gene)
Chr20 p12 NP_001002805 (RefSeq)
NM_001002805 (RefSeq)
chimpanzee LOC462577 462577 (Entrez Gene)
Chr6 XP_024212890 (RefSeq)
cattle C4A 280678 (Entrez Gene)
Chr23 P01030 (UniProt | EBI)
NM_001166485 (RefSeq)
dog LOC481722 481722 (Entrez Gene)
Chr12 XP_038473404 (RefSeq)
XM_538843 (RefSeq)
chicken C4 426611 (Entrez Gene)
Chr16 NP_001070701 (RefSeq)
NM_001077233 (RefSeq)
zebrafish c4b 794635 (Entrez Gene)
Chr16 NP_001352066 (RefSeq)
NM_001365137 (RefSeq)
frog, western clawed c4a 100135012 (Entrez Gene)
Chr8 NP_001107156 (RefSeq)
NM_001113684 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory