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Vertebrate Homology Class
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
3600

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human NLRP3 HGNC:16400 (HGNC)
114548 (Entrez Gene)
606416 (OMIM)
Chr1 q44 Chr1:247415945-247449108 (+)
GRCh38
CINCA Syndrome; CINCA
Familial Cold Autoinflammatory Syndrome 1; FCAS1
Muckle-Wells Syndrome; MWS
Q96P20 (UniProt | EBI)
NM_004895 (RefSeq)
mouse Nlrp3 MGI:2653833 (MGI)
216799 (Entrez Gene)
Gene Tree
VISTA-Point
Chr11 37.73 cM Chr11:59541568-59566955 (+)
GRCm38
CINCA Syndrome; CINCA
Familial Cold Autoinflammatory Syndrome 1; FCAS1
Muckle-Wells Syndrome; MWS
OTTMUSG00000005801 (VEGA)
OTTMUSP00000005970 (VEGA)
OTTMUST00000012840 (VEGA)
rat Nlrp3 287362 (Entrez Gene)
Chr10 q22 NP_001178571 (RefSeq)
NM_001191642 (RefSeq)
chimpanzee NLRP3 469743 (Entrez Gene)
Chr1 XP_001141114 (RefSeq)
rhesus macaque NLRP3 701278 (Entrez Gene)
Chr1 B0FPE9 (UniProt | EBI)
NM_001114351 (RefSeq)
cattle NLRP3 538639 (Entrez Gene)
Chr7 A6QLE5 (UniProt | EBI)
NM_001102219 (RefSeq)
dog NLRP3 490576 (Entrez Gene)
Chr8 XP_848377 (RefSeq)
chicken NLRP3 423021 (Entrez Gene)
Chr5 XP_001233262 (RefSeq)
NM_001031178 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory