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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human DOT1L HGNC:24948 (HGNC)
84444 (Entrez Gene)
607375 (OMIM)
DOT1L (MyGene.info)
HGNC homology
Chr19 p13.3 Chr19:2163963-2232578 (+)
Q8TEK3 (UniProt | EBI)
NM_032482 (RefSeq)
mouse Dot1l MGI:2143886 (MGI)
208266 (Entrez Gene)
Gene Tree
HGNC homology
Chr10 39.72 cM Chr10:80755206-80795461 (+)
dilated cardiomyopathy 1A
OTTMUSG00000017289 (VEGA)
OTTMUSP00000018849 (VEGA)
OTTMUST00000041909 (VEGA)
rat Dot1l 362831 (Entrez Gene)
Chr7 q11 NP_001102203 (RefSeq)
NM_001108733 (RefSeq)
chimpanzee DOT1L 455566 (Entrez Gene)
Chr19 XP_016790120 (RefSeq)
cattle DOT1L 510442 (Entrez Gene)
Chr7 XP_010805370 (RefSeq)
dog DOT1L 485073 (Entrez Gene)
Chr20 XP_005633296 (RefSeq)
chicken DOT1L 420078 (Entrez Gene)
Chr28 XP_015155355 (RefSeq)
zebrafish dot1l 559945 (Entrez Gene)
Chr22 XP_009294626 (RefSeq)
frog, western clawed dot1l 100497594 (Entrez Gene)
Chr1 XP_017952486 (RefSeq)
macaque, rhesus DOT1L 710033 (Entrez Gene)
Chr19 XP_014977895 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory