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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human NKX2-5 HGNC:2488 (HGNC)
1482 (Entrez Gene)
600584 (OMIM)
NKX2-5 (MyGene.info)
HGNC homology
Chr5 q35.1 Chr5:173232104-173235312 (-)
atrial heart septal defect 7
congenital nongoitrous hypothyroidism 5
double outlet right ventricle
hypoplastic left heart syndrome
tetralogy of Fallot
ventricular septal defect
P52952 (UniProt | EBI)
NM_004387 (RefSeq)
mouse Nkx2-5 MGI:97350 (MGI)
18091 (Entrez Gene)
Gene Tree
HGNC homology
Chr17 13.6 cM Chr17:26838664-26844995 (-)
atrial heart septal defect 7
congenital heart disease
hypoplastic left heart syndrome
tetralogy of Fallot
18091 (NCBI Gene Model)
P42582 (UniProt | EBI)
NM_008700 (RefSeq)
rat Nkx2-5 114109 (Entrez Gene)
Chr10 q12 O35767 (UniProt | EBI)
NM_053651 (RefSeq)
chimpanzee NKX2-5 462273 (Entrez Gene)
Chr5 XP_518104 (RefSeq)
cattle NKX2-5 538870 (Entrez Gene)
Chr20 NP_001039908 (RefSeq)
NM_001046443 (RefSeq)
dog NKX2-5 489113 (Entrez Gene)
Chr4 NP_001010959 (RefSeq)
NM_001010959 (RefSeq)
chicken NKX2-5 396073 (Entrez Gene)
Chr13 Q90788 (UniProt | EBI)
NM_205164 (RefSeq)
zebrafish nkx2.5 30696 (Entrez Gene)
Chr14 NP_571496 (RefSeq)
NM_131421 (RefSeq)
frog, western clawed nkx2-5 100144646 (Entrez Gene)
Chr3 NP_001116891 (RefSeq)
NM_001123419 (RefSeq)
macaque, rhesus NKX2-5 703795 (Entrez Gene)
Chr6 XP_001096796 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory