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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human NKX2-5 HGNC:2488 (HGNC)
1482 (Entrez Gene)
600584 (OMIM)
Chr5 q34 Chr5:173232104-173235312 (-)
Atrial Septal Defect 7 with or without Atrioventricular Conduction Defects; ASD7
Conotruncal Heart Malformations; CTHM
Hypoplastic Left Heart Syndrome 2; HLHS2
Hypothyroidism, Congenital, Nongoitrous, 5; CHNG5
Tetralogy of Fallot; TOF
Ventricular Septal Defect 3; VSD3
P52952 (UniProt | EBI)
NM_001166176 (RefSeq)
mouse Nkx2-5 MGI:97350 (MGI)
18091 (Entrez Gene)
Gene Tree
Chr17 13.6 cM Chr17:26838664-26841565 (-)
OTTMUSG00000037537 (VEGA)
OTTMUSP00000054102 (VEGA)
OTTMUST00000096774 (VEGA)
rat Nkx2-5 114109 (Entrez Gene)
Chr10 q12 O35767 (UniProt | EBI)
NM_053651 (RefSeq)
chimpanzee NKX2-5 462273 (Entrez Gene)
Chr5 XP_003311015 (RefSeq)
rhesus macaque NKX2-5 703795 (Entrez Gene)
Chr6 XP_014996911 (RefSeq)
cattle NKX2-5 538870 (Entrez Gene)
Chr20 NP_001039908 (RefSeq)
NM_001046443 (RefSeq)
dog NKX2-5 489113 (Entrez Gene)
Chr4 NP_001010959 (RefSeq)
NM_001010959 (RefSeq)
chicken NKX2-5 396073 (Entrez Gene)
Chr13 Q90788 (UniProt | EBI)
NM_205164 (RefSeq)
western clawed frog nkx2-5 100144646 (Entrez Gene)
ChrUN NP_001116891 (RefSeq)
NM_001123419 (RefSeq)
zebrafish nkx2.5 30696 (Entrez Gene)
Chr14 NP_571496 (RefSeq)
NM_131421 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory