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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human NOTCH1 HGNC:7881 (HGNC)
4851 (Entrez Gene)
190198 (OMIM)
Notch-1 (MyGene.info)
HGNC homology
Chr9 q34.3 Chr9:136494433-136545786 (-)
Adams-Oliver syndrome
aortic valve disease 1
P46531 (UniProt | EBI)
NM_017617 (RefSeq)
mouse Notch1 MGI:97363 (MGI)
18128 (Entrez Gene)
Gene Tree
HGNC homology
Chr2 18.91 cM Chr2:26457902-26503822 (-)
18128 (NCBI Gene Model)
Q01705 (UniProt | EBI)
NM_008714 (RefSeq)
rat Notch1 25496 (Entrez Gene)
Chr3 p13 Q07008 (UniProt | EBI)
NM_001105721 (RefSeq)
chimpanzee NOTCH1 464865 (Entrez Gene)
Chr9 XP_009455996 (RefSeq)
cattle NOTCH1 767866 (Entrez Gene)
Chr11 XP_024855411 (RefSeq)
dog NOTCH1 480676 (Entrez Gene)
Chr9 XP_005625490 (RefSeq)
chicken NOTCH1 395655 (Entrez Gene)
Chr17 NP_001025466 (RefSeq)
NM_001030295 (RefSeq)
zebrafish notch1b 794892 (Entrez Gene)
Chr5 NP_571377 (RefSeq)
NM_131302 (RefSeq)
frog, western clawed notch1 100037842 (Entrez Gene)
Chr8 A2RUV0 (UniProt | EBI)
NM_001097288 (RefSeq)
macaque, rhesus NOTCH1 709947 (Entrez Gene)
Chr15 XP_014971839 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory