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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human SMAD4 HGNC:6770 (HGNC)
4089 (Entrez Gene)
600993 (OMIM)
HGNC homology
Chr18 q21.2 Chr18:51030213-51085042 (+)
juvenile polyposis syndrome
pancreatic carcinoma
Q13485 (UniProt | EBI)
NM_005359 (RefSeq)
mouse Smad4 MGI:894293 (MGI)
17128 (Entrez Gene)
Gene Tree
HGNC homology
Chr18 49.51 cM Chr18:73639009-73703780 (-)
juvenile polyposis syndrome
osteogenesis imperfecta
OTTMUSG00000021090 (VEGA)
OTTMUSP00000023202 (VEGA)
OTTMUST00000049898 (VEGA)
rat Smad4 50554 (Entrez Gene)
Chr18 q12.2 O70437 (UniProt | EBI)
NM_019275 (RefSeq)
chimpanzee SMAD4 468537 (Entrez Gene)
Chr18 XP_024206614 (RefSeq)
cattle SMAD4 540248 (Entrez Gene)
Chr24 Q1HE26 (UniProt | EBI)
NM_001076209 (RefSeq)
dog SMAD4 476196 (Entrez Gene)
Chr1 XP_022272604 (RefSeq)
zebrafish smad4a 559111 (Entrez Gene)
Chr10 NP_001116172 (RefSeq)
NM_001122700 (RefSeq)
frog, western clawed smad4.1 100038088 (Entrez Gene)
Chr1 XP_002934485 (RefSeq)
macaque, rhesus SMAD4 701803 (Entrez Gene)
Chr18 NP_001248019 (RefSeq)
NM_001261090 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory