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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human TPMT HGNC:12014 (HGNC)
7172 (Entrez Gene)
187680 (OMIM)
Thiopurine methyltransferase (MyGene.info)
HGNC homology
Chr6 p22.3 Chr6:18128311-18155165 (-)
thiopurine S-methyltransferase deficiency
P51580 (UniProt | EBI)
NM_001346817 (RefSeq)
mouse Tpmt MGI:98812 (MGI)
22017 (Entrez Gene)
Gene Tree
HGNC homology
Chr13 24.5 cM Chr13:47025170-47044737 (-)
thiopurine S-methyltransferase deficiency
OTTMUSG00000024764 (VEGA)
OTTMUSP00000029822 (VEGA)
OTTMUST00000060976 (VEGA)
rat Tpmt 690050 (Entrez Gene)
Chr17 p14 Q9Z0T0 (UniProt | EBI)
NM_001079531 (RefSeq)
chimpanzee TPMT 471863 (Entrez Gene)
Chr6 Q3BCR8 (UniProt | EBI)
NM_001035519 (RefSeq)
cattle TPMT 511644 (Entrez Gene)
Chr23 Q17QQ2 (UniProt | EBI)
NM_001075531 (RefSeq)
dog TPMT 403536 (Entrez Gene)
Chr35 Q8HX86 (UniProt | EBI)
NM_001003015 (RefSeq)
chicken TPMT 420830 (Entrez Gene)
Chr2 XP_418921 (RefSeq)
zebrafish tpmt.1 436842 (Entrez Gene)
Chr19 Q504A5 (UniProt | EBI)
NM_001002569 (RefSeq)
tpmt.2 573111 (Entrez Gene)
Chr19 NP_001028758 (RefSeq)
NM_001033586 (RefSeq)
frog, western clawed tpmt 549164 (Entrez Gene)
Chr6 NP_001016410 (RefSeq)
NM_001016410 (RefSeq)
macaque, rhesus TPMT 704564 (Entrez Gene)
Chr4 XP_014991108 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory