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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human COMT HGNC:2228 (HGNC)
1312 (Entrez Gene)
116790 (OMIM)
Catechol-O-methyl transferase (MyGene.info)
HGNC homology
Chr22 q11.21 Chr22:19941740-19969975 (+)
panic disorder
P21964 (UniProt | EBI)
NM_000754 (RefSeq)
mouse Comt MGI:88470 (MGI)
12846 (Entrez Gene)
Gene Tree
HGNC homology
Chr16 11.4 cM Chr16:18407346-18426852 (-)
OTTMUSG00000026238 (VEGA)
OTTMUSP00000031924 (VEGA)
OTTMUST00000064320 (VEGA)
rat Comt 24267 (Entrez Gene)
Chr11 q23 P22734 (UniProt | EBI)
NM_012531 (RefSeq)
chimpanzee COMT 458655 (Entrez Gene)
Chr22 XP_003317144 (RefSeq)
cattle COMT 618278 (Entrez Gene)
Chr17 A7MBI7 (UniProt | EBI)
NM_001102317 (RefSeq)
dog COMT 445450 (Entrez Gene)
Chr26 NP_001004074 (RefSeq)
NM_001004074 (RefSeq)
chicken COMT 416783 (Entrez Gene)
Chr15 XP_004945546 (RefSeq)
frog, western clawed comt 549111 (Entrez Gene)
Chr1 NP_001016357 (RefSeq)
NM_001016357 (RefSeq)
comt.2 549911 (Entrez Gene)
Chr1 NP_001017157 (RefSeq)
NM_001017157 (RefSeq)
LOC100135405 100135405 (Entrez Gene)
Chr1 NP_001107540 (RefSeq)
NM_001114068 (RefSeq)
macaque, rhesus COMT 712548 (Entrez Gene)
Chr10 NP_001247941 (RefSeq)
NM_001261012 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory