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Vertebrate Homology Class
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human SHH HGNC:10848 (HGNC)
6469 (Entrez Gene)
600725 (OMIM)
Chr7 q36 Chr7:155802864-155812273 (-)
Holoprosencephaly 3; HPE3
Microphthalmia, Isolated, with Coloboma 5; MCOPCB5
Solitary Median Maxillary Central Incisor; SMMCI
Q15465 (UniProt | EBI)
NM_000193 (RefSeq)
mouse Shh MGI:98297 (MGI)
20423 (Entrez Gene)
Gene Tree
Chr5 14.39 cM Chr5:28456815-28467101 (-)
Brachydactyly, Type A1; BDA1
Holoprosencephaly 3; HPE3
OTTMUSG00000021299 (VEGA)
OTTMUSP00000023583 (VEGA)
OTTMUST00000050499 (VEGA)
rat Shh 29499 (Entrez Gene)
Chr4 q11 Q63673 (UniProt | EBI)
NM_017221 (RefSeq)
chimpanzee SHH 743371 (Entrez Gene)
Chr7 XP_001147185 (RefSeq)
rhesus macaque SHH 716553 (Entrez Gene)
Chr3 XP_001106515 (RefSeq)
cattle SHH 286821 (Entrez Gene)
Chr4 XP_010803022 (RefSeq)
dog SHH 608860 (Entrez Gene)
Chr16 XP_850450 (RefSeq)
chicken SHH 395615 (Entrez Gene)
Chr2 Q91035 (UniProt | EBI)
NM_204821 (RefSeq)
western clawed frog shh 100487601 (Entrez Gene)
ChrUN XP_002932544 (RefSeq)
zebrafish shha 30269 (Entrez Gene)
Chr7 Q92008 (UniProt | EBI)
NM_131063 (RefSeq)
shhb 30444 (Entrez Gene)
Chr2 Q90419 (UniProt | EBI)
NM_131199 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory