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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human BTK HGNC:1133 (HGNC)
695 (Entrez Gene)
300300 (OMIM)
Bruton's tyrosine kinase (MyGene.info)
HGNC homology
ChrX q22.1 ChrX:101349447-101390796 (-)
Bruton-type agammaglobulinemia
isolated growth hormone deficiency type III
Q06187 (UniProt | EBI)
NM_000061 (RefSeq)
mouse Btk MGI:88216 (MGI)
12229 (Entrez Gene)
Gene Tree
HGNC homology
ChrX 56.18 cM ChrX:134542336-134583570 (-)
Bruton-type agammaglobulinemia
OTTMUSG00000019307 (VEGA)
OTTMUSP00000020834 (VEGA)
OTTMUST00000046138 (VEGA)
rat Btk 367901 (Entrez Gene)
ChrX q32 NP_001007799 (RefSeq)
NM_001007798 (RefSeq)
chimpanzee BTK 465759 (Entrez Gene)
ChrX XP_024209015 (RefSeq)
cattle BTK 533459 (Entrez Gene)
ChrX NP_001029761 (RefSeq)
NM_001034589 (RefSeq)
dog BTK 492019 (Entrez Gene)
ChrX XP_549139 (RefSeq)
chicken BTK 374075 (Entrez Gene)
Chr4 Q8JH64 (UniProt | EBI)
NM_204233 (RefSeq)
zebrafish btk 568653 (Entrez Gene)
Chr14 XP_021336920 (RefSeq)
frog, western clawed btk 100170477 (Entrez Gene)
Chr8 NP_001123732 (RefSeq)
NM_001130260 (RefSeq)
macaque, rhesus BTK 703000 (Entrez Gene)
ChrX XP_014983301 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory