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Vertebrate Homology Class
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human APC HGNC:583 (HGNC)
324 (Entrez Gene)
611731 (OMIM)
Chr5 q21-q22 Chr5:112707505-112846239 (+)
Colorectal Cancer; CRC
Desmoid Disease, Hereditary
Familial Adenomatous Polyposis 1; FAP1
Gastric Cancer
Hepatocellular Carcinoma
P25054 (UniProt | EBI)
NM_000038 (RefSeq)
mouse Apc MGI:88039 (MGI)
11789 (Entrez Gene)
Gene Tree
Chr18 18.53 cM Chr18:34220924-34318608 (+)
Breast Cancer
Colorectal Cancer; CRC
Familial Adenomatous Polyposis 1; FAP1
Hepatocellular Carcinoma
Ovarian Cancer
Prostate Cancer
OTTMUSG00000035932 (VEGA)
OTTMUSP00000051004 (VEGA)
OTTMUST00000092329 (VEGA)
rat Apc 24205 (Entrez Gene)
Chr18 p12 P70478 (UniProt | EBI)
NM_012499 (RefSeq)
chimpanzee APC 461999 (Entrez Gene)
Chr5 XP_001143893 (RefSeq)
cattle APC 533233 (Entrez Gene)
Chr10 NP_001069454 (RefSeq)
NM_001075986 (RefSeq)
dog APC 479139 (Entrez Gene)
Chr3 XP_005618091 (RefSeq)
chicken APC 415607 (Entrez Gene)
ChrZ XP_001233411 (RefSeq)
western clawed frog apc 779466 (Entrez Gene)
ChrUN XP_002936457 (RefSeq)
zebrafish apc 386762 (Entrez Gene)
Chr10 NP_001137312 (RefSeq)
NM_001143840 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory