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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human SMN1 HGNC:11117 (HGNC)
6606 (Entrez Gene)
600354 (OMIM)
SMN1 (MyGene.info)
HGNC homology
Chr5 q13.2 Chr5:70924941-70953015 (+)
adult spinal muscular atrophy
intermediate spinal muscular atrophy
juvenile spinal muscular atrophy
Werdnig-Hoffmann disease
Q16637 (UniProt | EBI)
NM_022874 (RefSeq)
SMN2 HGNC:11118 (HGNC)
6607 (Entrez Gene)
601627 (OMIM)
SMN2 (MyGene.info)
HGNC homology
Chr5 q13.2 Chr5:70049523-70077595 (+)
juvenile spinal muscular atrophy
Q16637 (UniProt | EBI)
NM_017411 (RefSeq)
mouse Smn1 MGI:109257 (MGI)
20595 (Entrez Gene)
Gene Tree
HGNC homology
Chr13 52.99 cM Chr13:100124852-100137690 (+)
juvenile spinal muscular atrophy
Werdnig-Hoffmann disease
OTTMUSG00000033496 (VEGA)
OTTMUSP00000045374 (VEGA)
OTTMUST00000084239 (VEGA)
rat Smn1 64301 (Entrez Gene)
Chr2 q12 O35876 (UniProt | EBI)
NM_022509 (RefSeq)
chimpanzee LOC461829 461829 (Entrez Gene)
Chr5 XP_001156435 (RefSeq)
cattle SMN2 281492 (Entrez Gene)
Chr20 q14 O18870 (UniProt | EBI)
NM_175701 (RefSeq)
dog SMN 403896 (Entrez Gene)
Chr2 O02771 (UniProt | EBI)
NM_001003226 (RefSeq)
chicken SMN 374025 (Entrez Gene)
ChrZ NP_989530 (RefSeq)
NM_204199 (RefSeq)
zebrafish smn1 30432 (Entrez Gene)
Chr5 Q9W6S8 (UniProt | EBI)
NM_131191 (RefSeq)
frog, western clawed smn2 100101724 (Entrez Gene)
Chr1 NP_001093710 (RefSeq)
NM_001100240 (RefSeq)
macaque, rhesus SMN1 677703 (Entrez Gene)
Chr6 NP_001247593 (RefSeq)
NM_001260664 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory