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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human TPH2 HGNC:20692 (HGNC)
121278 (Entrez Gene)
607478 (OMIM)
TPH2 (MyGene.info)
HGNC homology
Chr12 q21.1 Chr12:71938846-72032441 (+)
attention deficit hyperactivity disorder
endogenous depression
Q8IWU9 (UniProt | EBI)
NM_173353 (RefSeq)
mouse Tph2 MGI:2651811 (MGI)
216343 (Entrez Gene)
Gene Tree
HGNC homology
Chr10 63.51 cM Chr10:115078641-115185022 (-)
endogenous depression
216343 (NCBI Gene Model)
Q8CGV2 (UniProt | EBI)
NM_173391 (RefSeq)
rat Tph2 317675 (Entrez Gene)
Chr7 q22 Q8CGU9 (UniProt | EBI)
NM_173839 (RefSeq)
chimpanzee TPH2 467070 (Entrez Gene)
Chr12 XP_522470 (RefSeq)
dog TPH2 481165 (Entrez Gene)
Chr10 NP_001184049 (RefSeq)
NM_001197120 (RefSeq)
chicken TPH2 408026 (Entrez Gene)
Chr1 NP_001001301 (RefSeq)
NM_001001301 (RefSeq)
zebrafish tph2 407712 (Entrez Gene)
Chr18 NP_999960 (RefSeq)
NM_001310068 (RefSeq)
frog, western clawed tph2 100486097 (Entrez Gene)
Chr3 XP_002940217 (RefSeq)
macaque, rhesus TPH2 664730 (Entrez Gene)
Chr11 Q2HZ26 (UniProt | EBI)
NM_001039946 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory