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Vertebrate Homology Class
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human NKX2-1 HGNC:11825 (HGNC)
7080 (Entrez Gene)
600635 (OMIM)
Chr14 q13 Chr14:36516397-36520225 (-)
Chorea, Benign Hereditary; BHC
Choreoathetosis and Congenital Hypothyroidism with or without Pulmonary Dysfunction; CAHTP
P43699 (UniProt | EBI)
NM_003317 (RefSeq)
mouse Nkx2-1 MGI:108067 (MGI)
21869 (Entrez Gene)
Gene Tree
Chr12 24.42 cM Chr12:56531958-56536908 (-)
OTTMUSG00000044396 (VEGA)
OTTMUSP00000065278 (VEGA)
OTTMUST00000116868 (VEGA)
rat Nkx2-1 25628 (Entrez Gene)
Chr6 P23441 (UniProt | EBI)
NM_013093 (RefSeq)
chimpanzee NKX2-1 452867 (Entrez Gene)
Chr14 XP_509911 (RefSeq)
rhesus macaque NKX2-1 696771 (Entrez Gene)
Chr7 XP_001089773 (RefSeq)
cattle NKX2-1 613713 (Entrez Gene)
Chr21 NP_001178387 (RefSeq)
NM_001191458 (RefSeq)
chicken NKX2-1 395322 (Entrez Gene)
Chr5 NP_989947 (RefSeq)
NM_204616 (RefSeq)
western clawed frog nkx2-1 100135015 (Entrez Gene)
ChrUN XP_002935383 (RefSeq)
zebrafish nkx2.1 81883 (Entrez Gene)
Chr17 NP_571851 (RefSeq)
NM_131776 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory