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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human NPC1 HGNC:7897 (HGNC)
4864 (Entrez Gene)
607623 (OMIM)
NPC1 (MyGene.info)
HGNC homology
Chr18 q11.2 Chr18:23506184-23586617 (-)
Niemann-Pick disease type C1
O15118 (UniProt | EBI)
NM_000271 (RefSeq)
mouse Npc1 MGI:1097712 (MGI)
18145 (Entrez Gene)
Gene Tree
HGNC homology
Chr18 6.15 cM Chr18:12189692-12236400 (-)
Niemann-Pick disease
Niemann-Pick disease type C1
ENSMUSG00000024413 (Ensembl Gene Model)
ENSMUSP00000025279 (Ensembl)
ENSMUST00000025279 (Ensembl)
rat Npc1 266732 (Entrez Gene)
Chr18 p13 NP_705888 (RefSeq)
NM_153624 (RefSeq)
chimpanzee NPC1 455338 (Entrez Gene)
Chr18 XP_024206759 (RefSeq)
cattle NPC1 286772 (Entrez Gene)
Chr24 NP_777183 (RefSeq)
NM_174758 (RefSeq)
dog NPC1 403698 (Entrez Gene)
Chr7 NP_001003107 (RefSeq)
NM_001003107 (RefSeq)
chicken NPC1 421076 (Entrez Gene)
Chr2 XP_004939840 (RefSeq)
zebrafish npc1 553330 (Entrez Gene)
Chr2 NP_001230804 (RefSeq)
NM_001243875 (RefSeq)
frog, western clawed npc1 100494646 (Entrez Gene)
Chr6 XP_004915269 (RefSeq)
macaque, rhesus NPC1 700835 (Entrez Gene)
Chr18 XP_014977153 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory