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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human PNP HGNC:7892 (HGNC)
4860 (Entrez Gene)
164050 (OMIM)
HGNC homology
Chr14 q11.2 Chr14:20469379-20478006 (+)
purine nucleoside phosphorylase deficiency
P00491 (UniProt | EBI)
NM_000270 (RefSeq)
mouse Pnp MGI:97365 (MGI)
18950 (Entrez Gene)
Gene Tree
HGNC homology
Chr14 26.31 cM Chr14:50944303-50953412 (+)
purine nucleoside phosphorylase deficiency
18950 (NCBI Gene Model)
P23492 (UniProt | EBI)
NM_013632 (RefSeq)
Pnp2 MGI:3712328 (MGI)
667034 (Entrez Gene)
Gene Tree
HGNC homology
Chr14 26.32 cM Chr14:50956141-50964751 (+)
667034 (NCBI Gene Model)
NP_001116843 (RefSeq)
NM_001123371 (RefSeq)
rat Pnp 290029 (Entrez Gene)
Chr15 p14 P85973 (UniProt | EBI)
NM_001106031 (RefSeq)
chimpanzee PNP 737850 (Entrez Gene)
Chr14 XP_009425680 (RefSeq)
cattle LOC790312 790312 (Entrez Gene)
Chr10 XP_002690791 (RefSeq)
PNP 493724 (Entrez Gene)
Chr10 P55859 (UniProt | EBI)
NM_001007818 (RefSeq)
dog PNP 475393 (Entrez Gene)
Chr15 XP_532617 (RefSeq)
XM_532617 (RefSeq)
chicken PNP 769958 (Entrez Gene)
Chr11 XP_025010153 (RefSeq)
frog, western clawed pnp 448370 (Entrez Gene)
Chr1 NP_001006720 (RefSeq)
NM_001006719 (RefSeq)
macaque, rhesus LOC710245 710245 (Entrez Gene)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory