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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human PTPN11 HGNC:9644 (HGNC)
5781 (Entrez Gene)
176876 (OMIM)
PTPN11 (MyGene.info)
HGNC homology
Chr12 q24.13 Chr12:112418732-112509913 (+)
juvenile myelomonocytic leukemia
LEOPARD syndrome
Noonan syndrome 1
Q06124 (UniProt | EBI)
NM_080601 (RefSeq)
mouse Ptpn11 MGI:99511 (MGI)
19247 (Entrez Gene)
Gene Tree
HGNC homology
Chr5 61.72 cM Chr5:121130533-121191397 (-)
dilated cardiomyopathy
disease of metabolism
hepatocellular adenoma
hypertrophic cardiomyopathy
juvenile myelomonocytic leukemia
LEOPARD syndrome
Noonan syndrome 1
OTTMUSG00000016267 (VEGA)
OTTMUSP00000072964 (VEGA)
OTTMUST00000138887 (VEGA)
rat Ptpn11 25622 (Entrez Gene)
Chr12 q16 P41499 (UniProt | EBI)
NM_001177593 (RefSeq)
chimpanzee PTPN11 467135 (Entrez Gene)
cattle PTPN11 533590 (Entrez Gene)
Chr17 XP_010812357 (RefSeq)
NM_001192779 (RefSeq)
dog PTPN11 477488 (Entrez Gene)
Chr26 XP_005636308 (RefSeq)
chicken PTPN11 395815 (Entrez Gene)
Chr15 Q90687 (UniProt | EBI)
NM_204968 (RefSeq)
zebrafish ptpn11a 333979 (Entrez Gene)
Chr10 NP_956140 (RefSeq)
NM_199846 (RefSeq)
macaque, rhesus PTPN11 712044 (Entrez Gene)
Chr11 NP_001248038 (RefSeq)
NM_001261109 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory