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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human MLH1 HGNC:7127 (HGNC)
4292 (Entrez Gene)
120436 (OMIM)
HGNC homology
Chr3 p21.3 Chr3:36993350-37050846 (+)
Colorectal Cancer, Hereditary Nonpolyposis, Type 2; HNPCC2
Mismatch Repair Cancer Syndrome; MMRCS
Muir-Torre Syndrome; MRTES
P40692 (UniProt | EBI)
NM_000249 (RefSeq)
mouse Mlh1 MGI:101938 (MGI)
17350 (Entrez Gene)
Gene Tree
HGNC homology
Chr9 60.92 cM Chr9:111228228-111271791 (-)
Colorectal Cancer, Hereditary Nonpolyposis, Type 2; HNPCC2
OTTMUSG00000031784 (VEGA)
OTTMUSP00000041918 (VEGA)
OTTMUST00000078764 (VEGA)
rat Mlh1 81685 (Entrez Gene)
Chr8 q32 P97679 (UniProt | EBI)
NM_031053 (RefSeq)
chimpanzee MLH1 747104 (Entrez Gene)
Chr3 XP_009443444 (RefSeq)
cattle MLH1 533652 (Entrez Gene)
Chr22 NP_001069462 (RefSeq)
NM_001075994 (RefSeq)
dog MLH1 477019 (Entrez Gene)
Chr23 XP_005634288 (RefSeq)
chicken MLH1 420729 (Entrez Gene)
Chr2 XP_418828 (RefSeq)
western clawed frog mlh1 100170640 (Entrez Gene)
ChrUN XP_002933455 (RefSeq)
zebrafish mlh1 393632 (Entrez Gene)
Chr13 NP_956953 (RefSeq)
NM_200659 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory